ENSMUSG00000023032


Mus musculus

Features
Gene ID: ENSMUSG00000023032
  
Biological name :Slc4a8
  
Synonyms : Q8JZR6 / Slc4a8 / solute carrier family 4 (anion exchanger), member 8
  
Possible biological names infered from orthology : Q2Y0W8 / solute carrier family 4 member 8
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F1
Gene start: 100761747
Gene end: 100823968
  
Corresponding Affymetrix probe sets: 10426924 (MoGene1.0st)   1419851_at (Mouse Genome 430 2.0 Array)   1423443_at (Mouse Genome 430 2.0 Array)   1439674_at (Mouse Genome 430 2.0 Array)   1441700_at (Mouse Genome 430 2.0 Array)   1456519_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023776
Ensembl peptide - ENSMUSP00000123864
Ensembl peptide - ENSMUSP00000125090
NCBI entrez gene - 59033     See in Manteia.
MGI - MGI:1928745
RefSeq - XM_017316718
RefSeq - NM_001347102
RefSeq - NM_021530
RefSeq - XM_006521225
RefSeq Peptide - NP_067505
RefSeq Peptide - NP_001334031
swissprot - Q8JZR6
swissprot - E0CYV1
Ensembl - ENSMUSG00000023032
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc4a8ENSDARG00000015531Danio rerio
 SLC4A8ENSGALG00000031274Gallus gallus
 Q2Y0W8ENSG00000050438Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5DTL9 / Slc4a10 / solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 / Q6U841* / solute carrier family 4 member 10*ENSMUSG0000002690476
Slc4a7 / solute carrier family 4, sodium bicarbonate cotransporter, member 7 / Q9Y6M7* / solute carrier family 4 member 7*ENSMUSG0000002173373
O88343 / Slc4a4 / solute carrier family 4 (anion exchanger), member 4 / Q9Y6R1* / solute carrier family 4 member 4*ENSMUSG0000006096151
Slc4a5 / solute carrier family 4 member 5 / Q9BY07*ENSMUSG0000006832345
Slc4a9 / anion exchange protein 4 isoform 5 / Q96Q91* / solute carrier family 4 member 9*ENSMUSG0000002448537
Slc4a2 / solute carrier family 4 (anion exchanger), member 2 / P04920* / solute carrier family 4 member 2*ENSMUSG0000002896235
P16283 / Slc4a3 / solute carrier family 4 (anion exchanger), member 3 / P48751* / solute carrier family 4 member 3*ENSMUSG0000000657635
P04919 / Slc4a1 / solute carrier family 4 (anion exchanger), member 1 / P02730* / solute carrier family 4 member 1 (Diego blood group)*ENSMUSG0000000657429
A2AJN7 / Slc4a11 / Sodium bicarbonate transporter-like protein 11 / Q8NBS3* / solute carrier family 4 member 11*ENSMUSG0000007479619


Protein motifs (from Interpro)
Interpro ID Name
 IPR003020  Bicarbonate transporter, eukaryotic
 IPR003024  Sodium bicarbonate cotransporter
 IPR011531  Bicarbonate transporter, C-terminal
 IPR013769  Band 3 cytoplasmic domain
 IPR016152  Phosphotransferase/anion transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006820 anion transport IEA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0015701 bicarbonate transport IEA
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032809 neuronal cell body membrane IDA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0005452 inorganic anion exchanger activity IEA
 molecular_functionGO:0008509 anion transmembrane transporter activity IEA
 molecular_functionGO:0008510 sodium:bicarbonate symporter activity IBA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015301 anion:anion antiporter activity IEA


Pathways (from Reactome)
Pathway description
Bicarbonate transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr