ENSMUSG00000006574


Mus musculus

Features
Gene ID: ENSMUSG00000006574
  
Biological name :Slc4a1
  
Synonyms : P04919 / Slc4a1 / solute carrier family 4 (anion exchanger), member 1
  
Possible biological names infered from orthology : P02730 / solute carrier family 4 member 1 (Diego blood group)
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 102348824
Gene end: 102366203
  
Corresponding Affymetrix probe sets: 10391649 (MoGene1.0st)   1416464_at (Mouse Genome 430 2.0 Array)   1431743_a_at (Mouse Genome 430 2.0 Array)   1434502_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006749
NCBI entrez gene - 20533     See in Manteia.
MGI - MGI:109393
RefSeq - NM_011403
RefSeq Peptide - NP_035533
swissprot - P04919
swissprot - Q53ZN9
Ensembl - ENSMUSG00000006574
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc4a1aENSDARG00000012881Danio rerio
 slc4a1bENSDARG00000024560Danio rerio
 P02730ENSG00000004939Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc4a2 / solute carrier family 4 (anion exchanger), member 2 / P04920* / solute carrier family 4 member 2*ENSMUSG0000002896256
P16283 / Slc4a3 / solute carrier family 4 (anion exchanger), member 3 / P48751* / solute carrier family 4 member 3*ENSMUSG0000000657653
Slc4a7 / solute carrier family 4, sodium bicarbonate cotransporter, member 7 / Q9Y6M7* / solute carrier family 4 member 7*ENSMUSG0000002173335
Q5DTL9 / Slc4a10 / solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 / Q6U841* / solute carrier family 4 member 10*ENSMUSG0000002690435
O88343 / Slc4a4 / solute carrier family 4 (anion exchanger), member 4 / Q9Y6R1* / solute carrier family 4 member 4*ENSMUSG0000006096135
Slc4a5 / solute carrier family 4 member 5 / Q9BY07*ENSMUSG0000006832334
Q8JZR6 / Slc4a8 / solute carrier family 4 (anion exchanger), member 8 / Q2Y0W8* / solute carrier family 4 member 8*ENSMUSG0000002303234
Slc4a9 / anion exchange protein 4 isoform 5 / Q96Q91* / solute carrier family 4 member 9*ENSMUSG0000002448532
A2AJN7 / Slc4a11 / Sodium bicarbonate transporter-like protein 11 / Q8NBS3* / solute carrier family 4 member 11*ENSMUSG0000007479622


Protein motifs (from Interpro)
Interpro ID Name
 IPR001717  Anion exchange protein
 IPR002977  Anion exchange protein 1
 IPR003020  Bicarbonate transporter, eukaryotic
 IPR011531  Bicarbonate transporter, C-terminal
 IPR013769  Band 3 cytoplasmic domain
 IPR016152  Phosphotransferase/anion transporter
 IPR018241  Anion exchange, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006820 anion transport ISO
 biological_processGO:0006821 chloride transport IDA
 biological_processGO:0015701 bicarbonate transport IEA
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0098656 anion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030018 Z disc ISS
 cellular_componentGO:0030863 cortical cytoskeleton IEA
 molecular_functionGO:0005452 inorganic anion exchanger activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008509 anion transmembrane transporter activity IEA
 molecular_functionGO:0008510 sodium:bicarbonate symporter activity IBA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity IEA
 molecular_functionGO:0015108 chloride transmembrane transporter activity IDA
 molecular_functionGO:0015301 anion:anion antiporter activity ISO
 molecular_functionGO:0030506 ankyrin binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Bicarbonate transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Ighmtm1Che/Ighmtm1Che
Genetic Background: involves: 129 * C57BL/6

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1l11Jus51/Slc4a1l11Jus51
Genetic Background: involves: C57BL/6J

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a1wan/Slc4a1wan
Genetic Background: C3H/HeJ-Slc4a1wan/J

Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

Allelic Composition: Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0000216 absent erythrocyte precursors "lack of progenitors of the erythrocyte lineage" [J:23061]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0000226 abnormal mean corpuscular volume "deviation from the norm for the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fbxw4Dac-2J/Fbxw4Dac-2J
Genetic Background: CBy.MRL-Fbxw4Dac-2J/J

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Fbxw4Dac-2J/Fbxw4Dac-2J
Genetic Background: CBy.MRL-Fbxw4Dac-2J/J

Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Slc4a1l11Jus51/Slc4a1l11Jus51
Genetic Background: involves: C57BL/6J

Allelic Composition: Slc4a1wan/Slc4a1wan
Genetic Background: C3H/HeJ-Slc4a1wan/J

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

 MP:0001586 abnormal erythrocyte count "altered number of red blood cells per volume in the bloodstream" [J:53370]
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Allelic Composition: Slc4a1l11Jus51/Slc4a1l11Jus51
Genetic Background: involves: C57BL/6J

 MP:0001588 hemoglobin abnormalities "defects in the levels or the function of the oxygen-carrying protein of erythrocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc4a1l11Jus51/Slc4a1l11Jus51
Genetic Background: involves: C57BL/6J

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001589 abnormal mean corpuscular hemoglobin "anomalies in the average levels of hemoglobin contained in an erythrocyte" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1l11Jus51/Slc4a1l11Jus51
Genetic Background: involves: C57BL/6J

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1l11Jus51/Slc4a1l11Jus51
Genetic Background: involves: C57BL/6J

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a1wan/Slc4a1wan
Genetic Background: C3H/HeJ-Slc4a1wan/J

 MP:0002594 low mean erythrocyte count "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1tm1Llp/Slc4a1wan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

Allelic Composition: Slc4a1tm1Phsl/Slc4a1+
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc4a1l11Jus51/Slc4a1l11Jus51
Genetic Background: involves: C57BL/6J

 MP:0002812 spherocytosis "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a1wan/Slc4a1wan
Genetic Background: C3H/HeJ-Slc4a1wan/J

Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002814 hyperchromasia "increased capacity of a cell to stain with dye; usually refers to staining of cell nuclei with hematoxylin" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1l11Jus51/Slc4a1l11Jus51
Genetic Background: involves: C57BL/6J

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a1wan/Slc4a1wan
Genetic Background: C3H/HeJ-Slc4a1wan/J

Allelic Composition: Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1l11Jus51/Slc4a1l11Jus51
Genetic Background: involves: C57BL/6J

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a1wan/Slc4a1wan
Genetic Background: C3H/HeJ-Slc4a1wan/J

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0003017 decreased circulating bicarbonate level "reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0003030 acidemia "increased concentration of H-ion in the blood or a fall below normal in pH" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0003708 binucleate "two nuclei present per cell body when one is expected; often due to failed cytokinesis" [pg:Philip Groth submission]
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Allelic Composition: Slc4a1wan/Slc4a1wan
Genetic Background: C3H/HeJ-Slc4a1wan/J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a1wan/Slc4a1wan
Genetic Background: C3H/HeJ-Slc4a1wan/J

Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

Allelic Composition: Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0005558 decreased creatinine clearance "less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008941 reticulocytopenia "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a1wan/Slc4a1wan
Genetic Background: C3H/HeJ-Slc4a1wan/J

 MP:0008997 increased blood osmolality "increase in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1l11Jus51/Slc4a1l11Jus51
Genetic Background: involves: C57BL/6J

Allelic Composition: Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0010074 stomatocytosis "deformation of red blood cells to a cup-like shape, with swelling and with an elongated area of central pallor, instead of the normal biconcave shape" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0010163 hemolysis "destruction of erythrocytes such that hemoglobin is released from the cells; may occur by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc4a1l11Jus51/Slc4a1l11Jus51
Genetic Background: involves: C57BL/6J

Allelic Composition: Slc4a1wan/Slc4a1wan
Genetic Background: C3H/HeJ-Slc4a1wan/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc4a1tm1Ahc/Slc4a1tm1Ahc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a1tm1Llp/Slc4a1tm1Llp
Genetic Background: B6;129S4-Slc4a1tm1Llp/J

 MP:0011176 abnormal erythroblast morphology "any structural anomaly of the nucleated precursor of erythrocytes" [ISBN:0-683-40008-8]
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Allelic Composition: Slc4a1wan/Slc4a1wan
Genetic Background: C3H/HeJ-Slc4a1wan/J

 MP:0011422 kidney medulla atrophy "acquired diminution of the size of the inner portion of the kidney consisting of the renal pyramids, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0012551 metabolic acidosis "decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006574 P04919 / Slc4a1 / solute carrier family 4 (anion exchanger), member 1 / P02730* / solute carrier family 4 member 1 (Diego blood group)*  / complex






 

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