ENSMUSG00000032366


Mus musculus

Features
Gene ID: ENSMUSG00000032366
  
Biological name :Tpm1
  
Synonyms : P58771 / Tpm1 / tropomyosin 1, alpha
  
Possible biological names infered from orthology : P09493 / tropomyosin 1
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: C
Gene start: 67022590
Gene end: 67049406
  
Corresponding Affymetrix probe sets: 10594661 (MoGene1.0st)   1423049_a_at (Mouse Genome 430 2.0 Array)   1423721_at (Mouse Genome 430 2.0 Array)   1447713_at (Mouse Genome 430 2.0 Array)   1456623_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109325
Ensembl peptide - ENSMUSP00000109323
Ensembl peptide - ENSMUSP00000109326
Ensembl peptide - ENSMUSP00000138784
Ensembl peptide - ENSMUSP00000138514
Ensembl peptide - ENSMUSP00000109337
Ensembl peptide - ENSMUSP00000109335
Ensembl peptide - ENSMUSP00000109331
Ensembl peptide - ENSMUSP00000109327
Ensembl peptide - ENSMUSP00000030185
Ensembl peptide - ENSMUSP00000034928
Ensembl peptide - ENSMUSP00000051888
Ensembl peptide - ENSMUSP00000109314
Ensembl peptide - ENSMUSP00000109315
Ensembl peptide - ENSMUSP00000109316
Ensembl peptide - ENSMUSP00000109317
Ensembl peptide - ENSMUSP00000109319
Ensembl peptide - ENSMUSP00000109320
NCBI entrez gene - 22003     See in Manteia.
MGI - MGI:98809
RefSeq - XM_011242716
RefSeq - NM_001164248
RefSeq - NM_001164249
RefSeq - NM_001164250
RefSeq - NM_001164251
RefSeq - NM_001164252
RefSeq - NM_001164253
RefSeq - NM_001164254
RefSeq - NM_001164255
RefSeq - NM_001164256
RefSeq - NM_024427
RefSeq - XM_006511039
RefSeq - XM_006511040
RefSeq - XM_006511041
RefSeq - XM_006511042
RefSeq - XM_006511043
RefSeq - XM_006511044
RefSeq - XM_006511045
RefSeq - XM_006511046
RefSeq - XM_006511049
RefSeq - XM_006511050
RefSeq - XM_006511051
RefSeq - XM_011242714
RefSeq - XM_011242715
RefSeq Peptide - NP_001157722
RefSeq Peptide - NP_001157723
RefSeq Peptide - NP_001157724
RefSeq Peptide - NP_001157725
RefSeq Peptide - NP_001157726
RefSeq Peptide - NP_001157727
RefSeq Peptide - NP_001157728
RefSeq Peptide - NP_077745
RefSeq Peptide - NP_001157720
RefSeq Peptide - NP_001157721
swissprot - E9Q452
swissprot - E9Q450
swissprot - F8WID5
swissprot - G5E8R0
swissprot - G5E8R1
swissprot - G5E8R2
swissprot - E9Q448
swissprot - S4R2U0
swissprot - B7ZNL3
swissprot - P58771
swissprot - Q545Y3
swissprot - Q564G1
swissprot - Q8BP43
swissprot - Q8BSH3
swissprot - S4R261
swissprot - E9Q456
swissprot - E9Q455
swissprot - E9Q454
swissprot - E9Q453
Ensembl - ENSMUSG00000032366
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpmaENSDARG00000033683Danio rerio
 zgc:171719ENSDARG00000087402Danio rerio
 TPM1ENSGALG00000003521Gallus gallus
 TPM1ENSG00000140416Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tpm2 / P58774 / tropomyosin 2, beta / P07951* / tropomyosin 2*ENSMUSG0000002846480
Tpm3 / P21107 / tropomyosin 3, gammaENSMUSG0000002794080
Tpm4 / Q6IRU2 / Tropomyosin alpha-4 chain / P67936* / tropomyosin 4*ENSMUSG0000003179963
Tpm3-rs7ENSMUSG0000005812663


Protein motifs (from Interpro)
Interpro ID Name
 IPR000533  Tropomyosin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0003065 positive regulation of heart rate by epinephrine IMP
 biological_processGO:0007015 actin filament organization IBA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060048 cardiac muscle contraction IMP
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904753 negative regulation of vascular associated smooth muscle cell migration IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005862 muscle thin filament tropomyosin TAS
 cellular_componentGO:0015629 actin cytoskeleton ISS
 cellular_componentGO:0030016 myofibril IDA
 cellular_componentGO:0031941 filamentous actin IDA
 cellular_componentGO:0032059 bleb IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0008307 structural constituent of muscle IBA
 molecular_functionGO:0042802 identical protein binding ISS
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046982 protein heterodimerization activity ISS
 molecular_functionGO:0051015 actin filament binding IBA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction
Smooth Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp4mdig/Lrp4mdig
Genetic Background: involves: 129S2/SvPas * DBA/1LacJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Lrp4mdig/Lrp4mdig
Genetic Background: involves: 129S2/SvPas * DBA/1LacJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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