ENSMUSG00000035299


Mus musculus

Features
Gene ID: ENSMUSG00000035299
  
Biological name :Mid1
  
Synonyms : E3 ubiquitin-protein ligase Midline-1 / Mid1 / O70583
  
Possible biological names infered from orthology : midline 1 / O15344
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F5
Gene start: 169685199
Gene end: 170005736
  
Corresponding Affymetrix probe sets: 10603208 (MoGene1.0st)   1422055_at (Mouse Genome 430 2.0 Array)   1438239_at (Mouse Genome 430 2.0 Array)   1443666_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126746
Ensembl peptide - ENSMUSP00000107735
Ensembl peptide - ENSMUSP00000128176
Ensembl peptide - ENSMUSP00000038765
Ensembl peptide - ENSMUSP00000077974
Ensembl peptide - ENSMUSP00000078412
Ensembl peptide - ENSMUSP00000107732
Ensembl peptide - ENSMUSP00000107733
NCBI entrez gene - 17318     See in Manteia.
MGI - MGI:1100537
RefSeq - XM_017318413
RefSeq - XM_006528736
RefSeq - XM_006528737
RefSeq - XM_006528739
RefSeq - XM_011247789
RefSeq - XM_017318408
RefSeq - XM_017318409
RefSeq - XM_017318410
RefSeq - XM_017318411
RefSeq - XM_017318412
RefSeq - NM_001290504
RefSeq - NM_001290505
RefSeq - NM_001290506
RefSeq - NM_001290512
RefSeq - NM_010797
RefSeq Peptide - NP_001277441
RefSeq Peptide - NP_001277433
RefSeq Peptide - NP_001277434
RefSeq Peptide - NP_001277435
RefSeq Peptide - NP_034927
swissprot - Q6PD02
swissprot - O70583
swissprot - B1AV01
swissprot - B1AUZ9
Ensembl - ENSMUSG00000035299
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mid1ENSDARG00000060482Danio rerio
 MID1ENSGALG00000038504Gallus gallus
 MID1ENSG00000101871Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mid2 / Mus musculus midline 2 (Mid2), transcript variant 2, mRNA. / Q9UJV3* / midline 2*ENSMUSG0000000026673
Q505D9 / Trim67 / Tripartite motif-containing protein 67 / Q6ZTA4* / tripartite motif containing 67*ENSMUSG0000003691326
Trim9 / Q8C7M3 / E3 ubiquitin-protein ligase TRIM9 / Q9C026* / tripartite motif containing 9*ENSMUSG0000002107126
Q7TNM2 / Trim46 / tripartite motif-containing 46 / Q7Z4K8*ENSMUSG0000004276626
Q80WG7 / Trim36 / E3 ubiquitin-protein ligase Trim36 / Q9NQ86* / tripartite motif containing 36*ENSMUSG0000003394925
Fsd1 / Q7TPM6 / Fibronectin type III and SPRY domain-containing protein 1 / Q9BTV5* / fibronectin type III and SPRY domain containing 1*ENSMUSG0000001158920
Fsd1l / Q8BYN5 / Mus musculus fibronectin type III and SPRY domain containing 1-like (Fsd1l), transcript variant 3, mRNA. / Q9BXM9* / fibronectin type III and SPRY domain containing 1 like*ENSMUSG0000005475219
Trim55 / tripartite motif-containing 55 / Q9BYV6*ENSMUSG0000006091318
Trim63 / tripartite motif-containing 63 / Q969Q1*ENSMUSG0000002883415
Q9ERP3 / Trim54 / Tripartite motif-containing protein 54 / Q9BYV2* / tripartite motif containing 54*ENSMUSG0000006207715


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR001870  B30.2/SPRY domain
 IPR003649  B-box, C-terminal
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR003961  Fibronectin type III
 IPR006574  SPRY-associated
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR017903  COS domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif
 IPR027727  Midline-1
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007026 negative regulation of microtubule depolymerization IGI
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IEA
 biological_processGO:0035372 protein localization to microtubule IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005881 cytoplasmic microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Robo4tm1Kzh/Robo4tm1Kzh,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr5a2tm1Lex/Nr5a2tm1Lex
Genetic Background: involves: 129

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004096 abnormal midbrain-hindbrain boundary development "anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Robo4tm1Kzh/Robo4tm1Kzh,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006097 abnormal cerebellar lobule formation "anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0006104 abnormal tectum morphology "any structural alterations or malfunction of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65762]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0009038 decreased inferior colliculus size "decreased size of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0009267 abnormal cerebellum fissure morphology "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0009964 abnormal cerebellum lobule morphology "any structural anomaly of the ten gyri of the cerebellar cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0009988 abnormal cerebellum vermis lobule I morphology 
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0009989 abnormal cerebellum vermis lobule II morphology 
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0009990 abnormal cerebellum vermis lobule III morphology 
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Mid1+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0012132 abnormal midbrain-hindbrain boundary morphology "any structural anomaly of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]
Show

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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