ENSMUSG00000062077


Mus musculus

Features
Gene ID: ENSMUSG00000062077
  
Biological name :Trim54
  
Synonyms : Q9ERP3 / Trim54 / Tripartite motif-containing protein 54
  
Possible biological names infered from orthology : Q9BYV2 / tripartite motif containing 54
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 31116712
Gene end: 31137630
  
Corresponding Affymetrix probe sets: 10520706 (MoGene1.0st)   1419440_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144629
Ensembl peptide - ENSMUSP00000013771
NCBI entrez gene - 58522     See in Manteia.
MGI - MGI:1889623
RefSeq - NM_021447
RefSeq Peptide - NP_067422
swissprot - E9QAT9
swissprot - Q9ERP3
Ensembl - ENSMUSG00000062077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trim54ENSDARG00000029907Danio rerio
 TRIM54ENSGALG00000033203Gallus gallus
 Q9BYV2ENSG00000138100Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trim55 / tripartite motif-containing 55 / Q9BYV6*ENSMUSG0000006091361
Trim63 / tripartite motif-containing 63 / Q969Q1*ENSMUSG0000002883457
Q80WG7 / Trim36 / E3 ubiquitin-protein ligase Trim36 / Q9NQ86* / tripartite motif containing 36*ENSMUSG0000003394930
Q7TNM2 / Trim46 / tripartite motif-containing 46 / Q7Z4K8*ENSMUSG0000004276629
Mid1 / O70583 / E3 ubiquitin-protein ligase Midline-1 / O15344* / midline 1*ENSMUSG0000003529928
Mid2 / Mus musculus midline 2 (Mid2), transcript variant 2, mRNA. / Q9UJV3* / midline 2*ENSMUSG0000000026627
Q505D9 / Trim67 / Tripartite motif-containing protein 67 / Q6ZTA4* / tripartite motif containing 67*ENSMUSG0000003691324
Trim9 / Q8C7M3 / E3 ubiquitin-protein ligase TRIM9 / Q9C026* / tripartite motif containing 9*ENSMUSG0000002107124
Fsd1 / Q7TPM6 / Fibronectin type III and SPRY domain-containing protein 1 / Q9BTV5* / fibronectin type III and SPRY domain containing 1*ENSMUSG0000001158911
Fsd1l / Q8BYN5 / Mus musculus fibronectin type III and SPRY domain containing 1-like (Fsd1l), transcript variant 3, mRNA. / Q9BXM9* / fibronectin type III and SPRY domain containing 1 like*ENSMUSG0000005475211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017903  COS domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif
 IPR033492  Tripartite motif-containing protein 54


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007026 negative regulation of microtubule depolymerization IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0055001 muscle cell development IEA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005875 microtubule associated complex IDA
 cellular_componentGO:0030018 Z disc IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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