ENSMUSG00000038718


Mus musculus

Features
Gene ID: ENSMUSG00000038718
  
Biological name :Pbx3
  
Synonyms : O35317 / Pbx3 / Pre-B-cell leukemia transcription factor 3
  
Possible biological names infered from orthology : P40426 / PBX homeobox 3
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 34171457
Gene end: 34373142
  
Corresponding Affymetrix probe sets: 10481857 (MoGene1.0st)   1421193_a_at (Mouse Genome 430 2.0 Array)   1447640_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119914
Ensembl peptide - ENSMUSP00000135838
Ensembl peptide - ENSMUSP00000135226
Ensembl peptide - ENSMUSP00000123567
Ensembl peptide - ENSMUSP00000045281
Ensembl peptide - ENSMUSP00000108757
Ensembl peptide - ENSMUSP00000114695
Ensembl peptide - ENSMUSP00000115710
NCBI entrez gene - 18516     See in Manteia.
MGI - MGI:97496
RefSeq - XM_006497784
RefSeq - NM_001290576
RefSeq - NM_016768
RefSeq - XM_006497782
RefSeq Peptide - NP_058048
RefSeq Peptide - NP_001277505
swissprot - D6RCU6
swissprot - B2FDH2
swissprot - H3BK27
swissprot - B2FDH3
swissprot - H3BLL9
swissprot - O35317
Ensembl - ENSMUSG00000038718
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pbx3aENSDARG00000089262Danio rerio
 pbx3bENSDARG00000013615Danio rerio
 PBX3ENSGALG00000000972Gallus gallus
 PBX3ENSG00000167081Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pbx1 / P41778 / Pre-B-cell leukemia transcription factor 1 / P40424* / PBX homeobox 1*ENSMUSG0000005253483
Pbx2 / O35984 / pre B cell leukemia homeobox 2 / P40425* / PBX homeobox 2*ENSMUSG0000003467374
Pbx4 / Q99NE9 / Mus musculus pre B cell leukemia homeobox 4 (Pbx4), transcript variant 4, mRNA. / Q9BYU1* / PBX homeobox 4*ENSMUSG0000003186054


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR005542  PBX
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0021516 dorsal spinal cord development IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048666 neuron development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2tm1Mlc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx3tm1Mlc/Pbx3+,Tg(Tcfap2a-cre)1Will/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx3tm1Mlc/Pbx3+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pbx1tm1Mlc/Pbx1+,Pbx2tm1Mlc/Pbx2+,Pbx3tm1Mlc/Pbx3+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Scd1tm1Ntam/Scd1tm1Ntam
Genetic Background: involves: C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Pbx3tm1.1Og/Pbx3tm1.1Og
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx3tm1Mlc/Pbx3+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0002321 hypoventilation "reduced alveolar ventiliation relative to metabolic carbon dioxide production; results in alveolar carbon dioxide pressure increasing above normal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx3tm1Mlc/Pbx3+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002863 improved righting response "faster ability or less amount of time needed to recover from supine position" [J:86936]
Show

Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0003578 absent ovary "absence of the female reproductive gland containing the germ cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
Show

Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx3tm1Mlc/Pbx3+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx3tm1Mlc/Pbx3+,Tg(Tcfap2a-cre)1Will/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx3tm1Mlc/Pbx3+
Genetic Background: involves: 129S6/SvEvTac

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0005423 abnormal somatic nervous system physiology "anomalous function of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0006282 abnormal posterior horn morphology "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0009904 tongue hypoplasia "underdevelopment of the tongue, usually due to a deficiency in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx3tm1Mlc/Pbx3+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb1tm1(cre)Og/Hoxb1+,Pbx3tm1Og/Pbx3tm1Og
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Pbx3tm1.1Og/Pbx3tm1.1Og
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pbx1tm1Mlc/Pbx1+,Pbx2tm1Mlc/Pbx2+,Pbx3tm1Mlc/Pbx3+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0030190 small snout "decreased size of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
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Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx3tm1Mlc/Pbx3+
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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