ENSMUSG00000038754


Mus musculus

Features
Gene ID: ENSMUSG00000038754
  
Biological name :Elovl3
  
Synonyms : Elongation of very long chain fatty acids protein 3 / Elovl3 / O35949
  
Possible biological names infered from orthology : ELOVL fatty acid elongase 3 / Q9HB03
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 46131897
Gene end: 46135307
  
Corresponding Affymetrix probe sets: 10463551 (MoGene1.0st)   1420722_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036357
NCBI entrez gene - 12686     See in Manteia.
MGI - MGI:1195976
RefSeq - NM_007703
RefSeq Peptide - NP_031729
swissprot - O35949
Ensembl - ENSMUSG00000038754
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ELOVL3ENSG00000119915Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Elovl6 / Q920L5 / Elongation of very long chain fatty acids protein 6 / Q9H5J4* / ELOVL fatty acid elongase 6*ENSMUSG0000004122044
Elovl7 / Q9D2Y9 / Elongation of very long chain fatty acids protein 7 / A1L3X0* / ELOVL fatty acid elongase 7*ENSMUSG0000002169625
Elovl1 / Q9JLJ5 / Elongation of very long chain fatty acids protein 1 / Q9BW60* / ELOVL fatty acid elongase 1*ENSMUSG0000000639025
Elovl4 / Q9EQC4 / Elongation of very long chain fatty acids protein 4 / Q9GZR5* / ELOVL fatty acid elongase 4*ENSMUSG0000003226222
Elovl2 / Q9JLJ4 / Elongation of very long chain fatty acids protein 2 / Q9NXB9* / ELOVL fatty acid elongase 2*ENSMUSG0000002136422
Elovl5 / Q8BHI7 / Elongation of very long chain fatty acids protein 5 / Q9NYP7* / ELOVL fatty acid elongase 5*ENSMUSG0000003234922


Protein motifs (from Interpro)
Interpro ID Name
 IPR002076  ELO family
 IPR030457  ELO family, conserved site
 IPR033679  Elongation of very long chain fatty acids protein 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006636 unsaturated fatty acid biosynthetic process IEA
 biological_processGO:0019367 fatty acid elongation, saturated fatty acid IMP
 biological_processGO:0030148 sphingolipid biosynthetic process IBA
 biological_processGO:0034625 fatty acid elongation, monounsaturated fatty acid IMP
 biological_processGO:0034626 fatty acid elongation, polyunsaturated fatty acid IEA
 biological_processGO:0042761 very long-chain fatty acid biosynthetic process ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IBA
 molecular_functionGO:0009922 fatty acid elongase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0102336 3-oxo-arachidoyl-CoA synthase activity IEA
 molecular_functionGO:0102337 3-oxo-cerotoyl-CoA synthase activity IEA
 molecular_functionGO:0102338 3-oxo-lignoceronyl-CoA synthase activity IEA
 molecular_functionGO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity IEA


Pathways (from Reactome)
Pathway description
Linoleic acid (LA) metabolism
alpha-linolenic acid (ALA) metabolism
Synthesis of very long-chain fatty acyl-CoAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000372 irregular coat pigmentation "uneven coloration of the hair" [J:65030]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002991 abnormal sebaceous gland physiology "anomalous fundtion of any of the small, sacculated organs found within the dermis that normally secrete sebum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002992 abnormal sebaceous lipid secretion "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003136 yellow coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is increased compared to wild-type agouti" [llw2:Linda L. Washburn, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005072 abnormal hair follicle melanin granule "anomalous pigment paricles in the hair follicles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011019 abnormal adaptive thermogenesis "anomaly in the regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [PMID:16836744]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0013146 eye lesions "lesions on or around the eyes" [MGI:Ahmad_Retha]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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