ENSMUSG00000021364


Mus musculus

Features
Gene ID: ENSMUSG00000021364
  
Biological name :Elovl2
  
Synonyms : Elongation of very long chain fatty acids protein 2 / Elovl2 / Q9JLJ4
  
Possible biological names infered from orthology : ELOVL fatty acid elongase 2 / Q9NXB9
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.3
Gene start: 41182381
Gene end: 41220405
  
Corresponding Affymetrix probe sets: 10408838 (MoGene1.0st)   1416444_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021793
Ensembl peptide - ENSMUSP00000114112
NCBI entrez gene - 54326     See in Manteia.
MGI - MGI:1858960
RefSeq - NM_001311121
RefSeq - NM_019423
RefSeq Peptide - NP_001298050
RefSeq Peptide - NP_062296
swissprot - Q9JLJ4
swissprot - Q543J1
swissprot - A0A0R4J1P7
Ensembl - ENSMUSG00000021364
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elovl2ENSDARG00000045414Danio rerio
 ELOVL2ENSGALG00000012748Gallus gallus
 ELOVL2ENSG00000197977Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Elovl5 / Q8BHI7 / Elongation of very long chain fatty acids protein 5 / Q9NYP7* / ELOVL fatty acid elongase 5*ENSMUSG0000003234958
Elovl4 / Q9EQC4 / Elongation of very long chain fatty acids protein 4 / Q9GZR5* / ELOVL fatty acid elongase 4*ENSMUSG0000003226243
Elovl7 / Q9D2Y9 / Elongation of very long chain fatty acids protein 7 / A1L3X0* / ELOVL fatty acid elongase 7*ENSMUSG0000002169637
Elovl1 / Q9JLJ5 / Elongation of very long chain fatty acids protein 1 / Q9BW60* / ELOVL fatty acid elongase 1*ENSMUSG0000000639033
Elovl6 / Q920L5 / Elongation of very long chain fatty acids protein 6 / Q9H5J4* / ELOVL fatty acid elongase 6*ENSMUSG0000004122022
Elovl3 / O35949 / Elongation of very long chain fatty acids protein 3 / Q9HB03* / ELOVL fatty acid elongase 3*ENSMUSG0000003875420


Protein motifs (from Interpro)
Interpro ID Name
 IPR002076  ELO family
 IPR030457  ELO family, conserved site
 IPR033680  Elongation of very long chain fatty acids protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000038 very long-chain fatty acid metabolic process IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006636 unsaturated fatty acid biosynthetic process IEA
 biological_processGO:0019367 fatty acid elongation, saturated fatty acid IEA
 biological_processGO:0030148 sphingolipid biosynthetic process IBA
 biological_processGO:0034625 fatty acid elongation, monounsaturated fatty acid IBA
 biological_processGO:0034626 fatty acid elongation, polyunsaturated fatty acid IEA
 biological_processGO:0042761 very long-chain fatty acid biosynthetic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IBA
 molecular_functionGO:0009922 fatty acid elongase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IDA
 molecular_functionGO:0102336 3-oxo-arachidoyl-CoA synthase activity IEA
 molecular_functionGO:0102337 3-oxo-cerotoyl-CoA synthase activity IEA
 molecular_functionGO:0102338 3-oxo-lignoceronyl-CoA synthase activity IEA
 molecular_functionGO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity IEA


Pathways (from Reactome)
Pathway description
Linoleic acid (LA) metabolism
alpha-linolenic acid (ALA) metabolism
Synthesis of very long-chain fatty acyl-CoAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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