ENSMUSG00000041220


Mus musculus

Features
Gene ID: ENSMUSG00000041220
  
Biological name :Elovl6
  
Synonyms : Elongation of very long chain fatty acids protein 6 / Elovl6 / Q920L5
  
Possible biological names infered from orthology : ELOVL fatty acid elongase 6 / Q9H5J4
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 129532355
Gene end: 129638495
  
Corresponding Affymetrix probe sets: 10495993 (MoGene1.0st)   1417403_at (Mouse Genome 430 2.0 Array)   1417404_at (Mouse Genome 430 2.0 Array)   1442656_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142832
Ensembl peptide - ENSMUSP00000143736
Ensembl peptide - ENSMUSP00000143143
Ensembl peptide - ENSMUSP00000143131
Ensembl peptide - ENSMUSP00000071351
NCBI entrez gene - 170439     See in Manteia.
MGI - MGI:2156528
RefSeq - NM_130450
RefSeq Peptide - NP_569717
swissprot - A0A0G2JFE8
swissprot - A0A0G2JFD6
swissprot - A0A0G2JGX5
swissprot - Q920L5
Ensembl - ENSMUSG00000041220
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elovl6ENSDARG00000004402Danio rerio
 ELOVL6ENSGALG00000012131Gallus gallus
 ELOVL6ENSG00000170522Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Elovl3 / O35949 / Elongation of very long chain fatty acids protein 3 / Q9HB03* / ELOVL fatty acid elongase 3*ENSMUSG0000003875445
Elovl7 / Q9D2Y9 / Elongation of very long chain fatty acids protein 7 / A1L3X0* / ELOVL fatty acid elongase 7*ENSMUSG0000002169626
Elovl1 / Q9JLJ5 / Elongation of very long chain fatty acids protein 1 / Q9BW60* / ELOVL fatty acid elongase 1*ENSMUSG0000000639025
Elovl2 / Q9JLJ4 / Elongation of very long chain fatty acids protein 2 / Q9NXB9* / ELOVL fatty acid elongase 2*ENSMUSG0000002136424
Elovl4 / Q9EQC4 / Elongation of very long chain fatty acids protein 4 / Q9GZR5* / ELOVL fatty acid elongase 4*ENSMUSG0000003226224
Elovl5 / Q8BHI7 / Elongation of very long chain fatty acids protein 5 / Q9NYP7* / ELOVL fatty acid elongase 5*ENSMUSG0000003234923


Protein motifs (from Interpro)
Interpro ID Name
 IPR002076  ELO family
 IPR030457  ELO family, conserved site
 IPR033675  Elongation of very long chain fatty acids protein 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0019367 fatty acid elongation, saturated fatty acid IEA
 biological_processGO:0030148 sphingolipid biosynthetic process IBA
 biological_processGO:0030497 fatty acid elongation IDA
 biological_processGO:0034625 fatty acid elongation, monounsaturated fatty acid IBA
 biological_processGO:0034626 fatty acid elongation, polyunsaturated fatty acid IBA
 biological_processGO:0042759 long-chain fatty acid biosynthetic process IEA
 biological_processGO:0042761 very long-chain fatty acid biosynthetic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 molecular_functionGO:0009922 fatty acid elongase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IDA
 molecular_functionGO:0102336 3-oxo-arachidoyl-CoA synthase activity IEA
 molecular_functionGO:0102337 3-oxo-cerotoyl-CoA synthase activity IEA
 molecular_functionGO:0102338 3-oxo-lignoceronyl-CoA synthase activity IEA
 molecular_functionGO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of very long-chain fatty acyl-CoAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0014172 decreased fatty acid oxidation 
Show

Allelic Composition: Dysfim/Dysfim,Large1myd/Large1myd
Genetic Background: involves: C57BL/6 * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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