ENSMUSG00000032262


Mus musculus

Features
Gene ID: ENSMUSG00000032262
  
Biological name :Elovl4
  
Synonyms : Elongation of very long chain fatty acids protein 4 / Elovl4 / Q9EQC4
  
Possible biological names infered from orthology : ELOVL fatty acid elongase 4 / Q9GZR5
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E2
Gene start: 83778692
Gene end: 83806277
  
Corresponding Affymetrix probe sets: 10595392 (MoGene1.0st)   1424306_at (Mouse Genome 430 2.0 Array)   1451308_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034796
Ensembl peptide - ENSMUSP00000139163
NCBI entrez gene - 83603     See in Manteia.
MGI - MGI:1933331
RefSeq - NM_148941
RefSeq Peptide - NP_683743
swissprot - Q9EQC4
swissprot - V9GXI2
Ensembl - ENSMUSG00000032262
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elovl4aENSDARG00000006773Danio rerio
 elovl4bENSDARG00000027495Danio rerio
 ELOVL4ENSGALG00000015876Gallus gallus
 ELOVL4ENSG00000118402Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Elovl2 / Q9JLJ4 / Elongation of very long chain fatty acids protein 2 / Q9NXB9* / ELOVL fatty acid elongase 2*ENSMUSG0000002136441
Elovl7 / Q9D2Y9 / Elongation of very long chain fatty acids protein 7 / A1L3X0* / ELOVL fatty acid elongase 7*ENSMUSG0000002169640
Elovl5 / Q8BHI7 / Elongation of very long chain fatty acids protein 5 / Q9NYP7* / ELOVL fatty acid elongase 5*ENSMUSG0000003234940
Elovl1 / Q9JLJ5 / Elongation of very long chain fatty acids protein 1 / Q9BW60* / ELOVL fatty acid elongase 1*ENSMUSG0000000639035
Elovl6 / Q920L5 / Elongation of very long chain fatty acids protein 6 / Q9H5J4* / ELOVL fatty acid elongase 6*ENSMUSG0000004122021
Elovl3 / O35949 / Elongation of very long chain fatty acids protein 3 / Q9HB03* / ELOVL fatty acid elongase 3*ENSMUSG0000003875419


Protein motifs (from Interpro)
Interpro ID Name
 IPR002076  ELO family
 IPR030457  ELO family, conserved site
 IPR033678  Elongation of very long chain fatty acids protein 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0019367 fatty acid elongation, saturated fatty acid IBA
 biological_processGO:0030148 sphingolipid biosynthetic process IBA
 biological_processGO:0034625 fatty acid elongation, monounsaturated fatty acid IBA
 biological_processGO:0034626 fatty acid elongation, polyunsaturated fatty acid IBA
 biological_processGO:0042761 very long-chain fatty acid biosynthetic process ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 molecular_functionGO:0009922 fatty acid elongase activity EXP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0102336 3-oxo-arachidoyl-CoA synthase activity IEA
 molecular_functionGO:0102337 3-oxo-cerotoyl-CoA synthase activity IEA
 molecular_functionGO:0102338 3-oxo-lignoceronyl-CoA synthase activity IEA
 molecular_functionGO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Elovl4tm3Kzh/Elovl4tm3Kzh,Tg(Rho-icre)1Ck/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Mstntm1.1Swel/Mstntm1.1Swel
Genetic Background: involves: 129S7/SvEvBrd-Hprt1 * C57BL/6J * FVB/N

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
Show

Allelic Composition: Elovl4tm1Kzh/Elovl4tm1Kzh
Genetic Background: involves: C57BL/6

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Elovl4tm1Kzh/Elovl4tm1Kzh
Genetic Background: involves: C57BL/6

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mstntm1.1Swel/Mstntm1.1Swel
Genetic Background: involves: 129S7/SvEvBrd-Hprt1 * C57BL/6J * FVB/N

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mstntm1.1Swel/Mstntm1.1Swel
Genetic Background: involves: 129S7/SvEvBrd-Hprt1 * C57BL/6J * FVB/N

Allelic Composition: Elovl4tm1Kzh/Elovl4tm1Kzh
Genetic Background: involves: C57BL/6

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mstntm1.1Swel/Mstntm1.1Swel
Genetic Background: involves: 129S7/SvEvBrd-Hprt1 * C57BL/6J * FVB/N

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx2tm1Mjo/Runx2+,Satb2tm1Rug/Satb2+
Genetic Background: Not Specified

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Elovl4tm1Kzh/Elovl4tm1Kzh
Genetic Background: involves: C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Mstntm1.1Swel/Mstntm1.1Swel
Genetic Background: involves: 129S7/SvEvBrd-Hprt1 * C57BL/6J * FVB/N

Allelic Composition: Elovl4tm1Kzh/Elovl4tm1Kzh
Genetic Background: involves: C57BL/6

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Elovl4tm1Kzh/Elovl4+
Genetic Background: involves: C57BL/6

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

Allelic Composition: Elovl4tm1Kzh/Elovl4+
Genetic Background: involves: C57BL/6

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Elovl4tm1Kzh/Elovl4+
Genetic Background: involves: C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elovl4tm1Kzh/Elovl4tm1Kzh
Genetic Background: involves: C57BL/6

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mstntm1.1Swel/Mstntm1.1Swel
Genetic Background: involves: 129S7/SvEvBrd-Hprt1 * C57BL/6J * FVB/N

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005285 decreased unsaturated fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain has one or more double or triple carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Elovl4tm3Kzh/Elovl4tm3Kzh,Tg(Rho-icre)1Ck/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elovl4tm1Kzh/Elovl4tm1Kzh
Genetic Background: involves: C57BL/6

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elovl4tm1Kzh/Elovl4tm1Kzh
Genetic Background: involves: C57BL/6

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Mstntm1.1Swel/Mstntm1.1Swel
Genetic Background: involves: 129S7/SvEvBrd-Hprt1 * C57BL/6J * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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