ENSMUSG00000006390


Mus musculus

Features
Gene ID: ENSMUSG00000006390
  
Biological name :Elovl1
  
Synonyms : Elongation of very long chain fatty acids protein 1 / Elovl1 / Q9JLJ5
  
Possible biological names infered from orthology : ELOVL fatty acid elongase 1 / Q9BW60
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.1
Gene start: 118428093
Gene end: 118432953
  
Corresponding Affymetrix probe sets: 10507539 (MoGene1.0st)   1425676_a_at (Mouse Genome 430 2.0 Array)   1443820_x_at (Mouse Genome 430 2.0 Array)   1455994_x_at (Mouse Genome 430 2.0 Array)   1456530_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006557
Ensembl peptide - ENSMUSP00000064816
Ensembl peptide - ENSMUSP00000099734
Ensembl peptide - ENSMUSP00000126685
NCBI entrez gene - 54325     See in Manteia.
MGI - MGI:1858959
RefSeq - XM_006503233
RefSeq - NM_001039175
RefSeq - NM_001039176
RefSeq - NM_019422
RefSeq Peptide - NP_001034265
RefSeq Peptide - NP_062295
RefSeq Peptide - NP_001034264
swissprot - Q4V9V3
swissprot - Q548M4
swissprot - Q9JLJ5
Ensembl - ENSMUSG00000006390
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elovl1aENSDARG00000099960Danio rerio
 elovl1bENSDARG00000103735Danio rerio
 ELOVL1ENSGALG00000009988Gallus gallus
 ELOVL1ENSG00000066322Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Elovl7 / Q9D2Y9 / Elongation of very long chain fatty acids protein 7 / A1L3X0* / ELOVL fatty acid elongase 7*ENSMUSG0000002169656
Elovl4 / Q9EQC4 / Elongation of very long chain fatty acids protein 4 / Q9GZR5* / ELOVL fatty acid elongase 4*ENSMUSG0000003226239
Elovl5 / Q8BHI7 / Elongation of very long chain fatty acids protein 5 / Q9NYP7* / ELOVL fatty acid elongase 5*ENSMUSG0000003234935
Elovl2 / Q9JLJ4 / Elongation of very long chain fatty acids protein 2 / Q9NXB9* / ELOVL fatty acid elongase 2*ENSMUSG0000002136434
Elovl3 / O35949 / Elongation of very long chain fatty acids protein 3 / Q9HB03* / ELOVL fatty acid elongase 3*ENSMUSG0000003875425
Elovl6 / Q920L5 / Elongation of very long chain fatty acids protein 6 / Q9H5J4* / ELOVL fatty acid elongase 6*ENSMUSG0000004122024


Protein motifs (from Interpro)
Interpro ID Name
 IPR002076  ELO family
 IPR030457  ELO family, conserved site
 IPR033681  Elongation of very long chain fatty acids protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006636 unsaturated fatty acid biosynthetic process IEA
 biological_processGO:0019367 fatty acid elongation, saturated fatty acid IBA
 biological_processGO:0030148 sphingolipid biosynthetic process IMP
 biological_processGO:0034625 fatty acid elongation, monounsaturated fatty acid IBA
 biological_processGO:0034626 fatty acid elongation, polyunsaturated fatty acid IBA
 biological_processGO:0035338 long-chain fatty-acyl-CoA biosynthetic process IEA
 biological_processGO:0042761 very long-chain fatty acid biosynthetic process ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IBA
 molecular_functionGO:0009922 fatty acid elongase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0102336 3-oxo-arachidoyl-CoA synthase activity IEA
 molecular_functionGO:0102337 3-oxo-cerotoyl-CoA synthase activity IEA
 molecular_functionGO:0102338 3-oxo-lignoceronyl-CoA synthase activity IEA
 molecular_functionGO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity IEA


Pathways (from Reactome)
Pathway description
Linoleic acid (LA) metabolism
alpha-linolenic acid (ALA) metabolism
Synthesis of very long-chain fatty acyl-CoAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Cxcr2tm1Rmra/Cxcr2tm1Rmra,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
Show

Allelic Composition: Cxcr2tm1Rmra/Cxcr2tm1Rmra,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Cxcr2tm1Rmra/Cxcr2tm1Rmra,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cxcr2tm1Rmra/Cxcr2tm1Rmra,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cxcr2tm1Rmra/Cxcr2tm1Rmra,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA

 MP:0009608 abnormal lamellar body morphology "any structural anomaly of a membrane-bounded organelle, specialized for the storage and secretion various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae" [GO:0042599]
Show

Allelic Composition: Cxcr2tm1Rmra/Cxcr2tm1Rmra,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Cxcr2tm1Rmra/Cxcr2tm1Rmra,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA

 MP:0009823 abnormal sphingomyelin level "deviation in the expected amount of any of a group of phospholipids that are found especially in, but not restricted to, nerve tissue and yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cxcr2tm1Rmra/Cxcr2tm1Rmra,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cxcr2tm1Rmra/Cxcr2tm1Rmra,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cxcr2tm1Rmra/Cxcr2tm1Rmra,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA

 MP:0012232 abnormal ceramide level 
Show

Allelic Composition: Cxcr2tm1Rmra/Cxcr2tm1Rmra,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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