ENSMUSG00000039652


Mus musculus

Features
Gene ID: ENSMUSG00000039652
  
Biological name :Cpeb3
  
Synonyms : Cpeb3 / Cytoplasmic polyadenylation element-binding protein 3 / Q7TN99
  
Possible biological names infered from orthology : Q8NE35
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C2
Gene start: 37021291
Gene end: 37208601
  
Corresponding Affymetrix probe sets: 10467216 (MoGene1.0st)   1437765_at (Mouse Genome 430 2.0 Array)   1445868_at (Mouse Genome 430 2.0 Array)   1455372_at (Mouse Genome 430 2.0 Array)   1456048_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116749
Ensembl peptide - ENSMUSP00000116309
Ensembl peptide - ENSMUSP00000117242
Ensembl peptide - ENSMUSP00000123080
Ensembl peptide - ENSMUSP00000122442
Ensembl peptide - ENSMUSP00000121987
Ensembl peptide - ENSMUSP00000120416
Ensembl peptide - ENSMUSP00000118723
Ensembl peptide - ENSMUSP00000078690
Ensembl peptide - ENSMUSP00000115038
Ensembl peptide - ENSMUSP00000115656
Ensembl peptide - ENSMUSP00000116172
NCBI entrez gene - 208922     See in Manteia.
MGI - MGI:2443075
RefSeq - XM_011247210
RefSeq - NM_001290827
RefSeq - NM_001290828
RefSeq - NM_001290829
RefSeq - NM_198300
RefSeq - XM_006526829
RefSeq - XM_006526830
RefSeq - XM_006526831
RefSeq - XM_006526832
RefSeq - XM_006526833
RefSeq - XM_006526834
RefSeq - XM_006526839
RefSeq - XM_011247207
RefSeq - XM_011247208
RefSeq - XM_011247209
RefSeq - NM_001290826
RefSeq Peptide - NP_001277756
RefSeq Peptide - NP_001277757
RefSeq Peptide - NP_001277758
RefSeq Peptide - NP_938042
RefSeq Peptide - NP_001277755
swissprot - F6T0J8
swissprot - D3YUL6
swissprot - Q7TN99
swissprot - A0A0R4J102
swissprot - D3Z5R9
swissprot - D3Z5F3
swissprot - D3Z3Z5
swissprot - D3Z1R6
swissprot - D3YXB8
Ensembl - ENSMUSG00000039652
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpeb3ENSDARG00000060103Danio rerio
 CPEB3ENSGALG00000006912Gallus gallus
 CPEB3ENSG00000107864Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cpeb2 / cytoplasmic polyadenylation element-binding protein 2 isoform 1 / Q7Z5Q1* / cytoplasmic polyadenylation element binding protein 2*ENSMUSG0000003978262
Cpeb4 / Q7TN98 / Cytoplasmic polyadenylation element-binding protein 4 / Q17RY0*ENSMUSG0000002030060
Cpeb1 / P70166 / Mus musculus cytoplasmic polyadenylation element binding protein 1 (Cpeb1), transcript variant 4, mRNA. / RPS17* / P08708* / Q9BZB8* / AC245033.1* / ribosomal protein S17* ...ENSMUSG0000002558623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR011989  Armadillo-like helical
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR032296  Cytoplasmic polyadenylation element-binding protein, ZZ domain
 IPR034819  Cytoplasmic polyadenylation element-binding protein
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007616 long-term memory IMP
 biological_processGO:0017148 negative regulation of translation ISO
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0050955 thermoception IMP
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
 biological_processGO:0060998 regulation of dendritic spine development IMP
 biological_processGO:0060999 positive regulation of dendritic spine development IDA
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization ISO
 biological_processGO:0071230 cellular response to amino acid stimulus ISO
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
 biological_processGO:1900248 negative regulation of cytoplasmic translational elongation IDA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IMP
 biological_processGO:1900365 positive regulation of mRNA polyadenylation IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030014 CCR4-NOT complex ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0097440 apical dendrite IDA
 cellular_componentGO:1990124 messenger ribonucleoprotein complex IBA
 molecular_functionGO:0000900 translation repressor activity, mRNA regulatory element binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008135 translation factor activity, RNA binding IDA
 molecular_functionGO:0035613 RNA stem-loop binding IDA
 molecular_functionGO:0035925 mRNA 3"-UTR AU-rich region binding IDA
 molecular_functionGO:0043022 ribosome binding IBA
 molecular_functionGO:0045182 translation regulator activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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