ENSMUSG00000025586


Mus musculus

Features
Gene ID: ENSMUSG00000025586
  
Biological name :Cpeb1
  
Synonyms : Cpeb1 / Mus musculus cytoplasmic polyadenylation element binding protein 1 (Cpeb1), transcript variant 4, mRNA. / P70166
  
Possible biological names infered from orthology : AC245033.1 / cytoplasmic polyadenylation element binding protein 1 / P08708 / Q9BZB8 / ribosomal protein S17 / RPS17
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D3
Gene start: 81347026
Gene end: 81455465
  
Corresponding Affymetrix probe sets: 10565089 (MoGene1.0st)   1417960_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095936
Ensembl peptide - ENSMUSP00000120139
Ensembl peptide - ENSMUSP00000137079
NCBI entrez gene - 12877     See in Manteia.
MGI - MGI:108442
RefSeq - XM_017321965
RefSeq - NM_001252525
RefSeq - NM_001252526
RefSeq - NM_001357107
RefSeq - NM_007755
RefSeq - XM_011250785
RefSeq - XM_011250786
RefSeq - XM_011250787
RefSeq - XM_011250788
RefSeq - XM_011250790
RefSeq - XM_011250792
RefSeq - XM_017321964
RefSeq - XM_011250784
RefSeq Peptide - NP_001239454
RefSeq Peptide - NP_001239455
RefSeq Peptide - NP_001344036
RefSeq Peptide - NP_031781
swissprot - P70166
swissprot - Q059Z2
swissprot - F6X7Z3
Ensembl - ENSMUSG00000025586
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpeb1aENSDARG00000045932Danio rerio
 cpeb1bENSDARG00000008454Danio rerio
 CPEB1ENSGALG00000002150Gallus gallus
 AC245033.1ENSG00000260836Homo sapiens
 CPEB1ENSG00000214575Homo sapiens
 RPS17ENSG00000182774Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cpeb4 / Q7TN98 / Cytoplasmic polyadenylation element-binding protein 4 / Q17RY0*ENSMUSG0000002030031
Cpeb3 / Q7TN99 / Cytoplasmic polyadenylation element-binding protein 3 / Q8NE35*ENSMUSG0000003965229
Cpeb2 / cytoplasmic polyadenylation element-binding protein 2 isoform 1 / Q7Z5Q1* / cytoplasmic polyadenylation element binding protein 2*ENSMUSG0000003978228


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR032292  Cytoplasmic polyadenylation element-binding protein 1, N-terminal
 IPR032296  Cytoplasmic polyadenylation element-binding protein, ZZ domain
 IPR034819  Cytoplasmic polyadenylation element-binding protein
 IPR034977  CPEB-1, RNA recognition motif 1
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007130 synaptonemal complex assembly IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032869 cellular response to insulin stimulus ISO
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IMP
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:2000766 negative regulation of cytoplasmic translation IDA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045202 synapse IBA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0072687 meiotic spindle IDA
 cellular_componentGO:1990124 messenger ribonucleoprotein complex IBA
 molecular_functionGO:0000900 translation repressor activity, mRNA regulatory element binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008135 translation factor activity, RNA binding IBA
 molecular_functionGO:0035925 mRNA 3"-UTR AU-rich region binding IDA
 molecular_functionGO:0043022 ribosome binding IBA
 molecular_functionGO:0045182 translation regulator activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0003578 absent ovary "absence of the female reproductive gland containing the germ cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0003582 abnormal ovary development "abnormal morphogenesis of the female reproductive gland containing the germ cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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