ENSMUSG00000040669


Mus musculus

Features
Gene ID: ENSMUSG00000040669
  
Biological name :Phc1
  
Synonyms : Mus musculus polyhomeotic 1 (Phc1), transcript variant 5, mRNA. / Phc1
  
Possible biological names infered from orthology : P78364 / polyhomeotic homolog 1
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F1
Gene start: 122317731
Gene end: 122340561
  
Corresponding Affymetrix probe sets: 10547597 (MoGene1.0st)   1423212_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124795
Ensembl peptide - ENSMUSP00000125717
Ensembl peptide - ENSMUSP00000125580
Ensembl peptide - ENSMUSP00000125568
Ensembl peptide - ENSMUSP00000125545
Ensembl peptide - ENSMUSP00000125110
Ensembl peptide - ENSMUSP00000125030
Ensembl peptide - ENSMUSP00000078514
Ensembl peptide - ENSMUSP00000080532
Ensembl peptide - ENSMUSP00000108219
Ensembl peptide - ENSMUSP00000123911
Ensembl peptide - ENSMUSP00000123957
Ensembl peptide - ENSMUSP00000124678
Ensembl peptide - ENSMUSP00000124744
NCBI entrez gene - 13619     See in Manteia.
MGI - MGI:103248
RefSeq - XM_017321382
RefSeq - NM_001042623
RefSeq - NM_001271579
RefSeq - NM_001355215
RefSeq - NM_007905
RefSeq - XM_006505498
RefSeq - XM_006505499
RefSeq - XM_006505500
RefSeq - XM_017321381
RefSeq Peptide - NP_001258508
RefSeq Peptide - NP_001342144
RefSeq Peptide - NP_031931
RefSeq Peptide - NP_001036088
swissprot - E0CXC9
swissprot - E0CXA6
swissprot - F7D980
swissprot - E0CYR2
swissprot - Q7TT35
swissprot - Q3V116
swissprot - E0CYV8
swissprot - E0CXV8
swissprot - E0CXT0
Ensembl - ENSMUSG00000040669
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phc1ENSDARG00000002971Danio rerio
 PHC1ENSGALG00000014263Gallus gallus
 PHC1ENSG00000111752Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Phc2 / Q9QWH1 / Polyhomeotic-like protein 2 / Q8IXK0* / polyhomeotic homolog 2*ENSMUSG0000002879632
Phc3 / Q8CHP6 / Polyhomeotic-like protein 3 / Q8NDX5* / polyhomeotic homolog 3*ENSMUSG0000003765231
Q1RNF8 / Samd11 / Sterile alpha motif domain-containing protein 11 / Q96NU1* / sterile alpha motif domain containing 11*ENSMUSG000000963519
Samd7 / Q8C8Y5 / Sterile alpha motif domain-containing protein 7 / Q7Z3H4* / sterile alpha motif domain containing 7*ENSMUSG000000518607


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR012313  Zinc finger, FCS-type
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016574 histone ubiquitination IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0031519 PcG protein complex IEA
 cellular_componentGO:0035102 PRC1 complex IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000030 abnormal tympanic ring morphology "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000080 abnormal exoccipital bone morphology "malformed lateral part of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000104 abnormal sphenoid bone morphology "malformed irregularly shaped bone of the base of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Phc1tm1Os/Phc1tm1Os
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

Allelic Composition: Phc1tm1Os/Phc1tm1Os
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

Allelic Composition: Phc1tm1Os/Phc1tm1Os,Tg(Myh7-Phc1)#Yota/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Phc1tm1Os/Phc1+,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: T/tw3
Genetic Background: Not Specified

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Phc1tm1Os/Phc1tm1Os,Phc2tm1Hko/Phc2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Phc1tm1Os/Phc1+,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003494 parathyroid hypoplasia 
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004269 abnormal optic cup morphology "any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0004342 scapular bone foramen "presence of a hole in either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Phc1tm1Os/Phc1tm1Os,Phc2tm1Hko/Phc2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Phc1tm1Os/Phc1+,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004441 small occipital bone "reduced size of the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0004448 abnormal presphenoid bone morphology "any structural anomaly of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Phc1tm1Os/Phc1tm1Os
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004449 absent presphenoid bone "absence of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Phc1tm1Os/Phc1tm1Os,Phc2tm1Hko/Phc2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0005269 abnormal occipital bone morphology "anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Phc1tm1Os/Phc1+,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Phc1tm1Os/Phc1tm1Os
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Phc1tm1Os/Phc1+,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006117 aortic valve stenosis "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0006128 pulmonary valve stenosis "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0006337 abnormal first branchial arch morphology "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006338 abnormal second branchial arch morphology "anomaly in the structure of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Phc1tm1Os/Phc1tm1Os,Phc2tm1Hko/Phc2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Phc1tm1Os/Phc1+,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

Allelic Composition: Phc1tm1Os/Phc1tm1Os,Phc2tm1Hko/Phc2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Phc1tm1Os/Phc1+,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Phc1tm1Os/Phc1tm1Os
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

Allelic Composition: Phc1tm1Os/Phc1tm1Os,Tg(Myh7-Phc1)#Yota/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Phc1tm1Os/Phc1tm1Os,Tg(Myh7-Phc1)#Yota/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010428 abnormal heart right ventricle outflow tract morphology "any structural anomaly of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0010458 pulmonary trunk hypoplasia "underdevelopment or reduced size of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery, usually due to reduced cell number" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0010568 abnormal bulbus cordis morphology "any structural anomaly of a transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

Allelic Composition: Phc1tm1Os/Phc1tm1Os,Phc2tm1Hko/Phc2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Phc1tm1Os/Phc1+,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Phc1tm1Os/Phc1tm1Os
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012062 small tail bud "decreased size or area of the primordial region of the embryo that arises to form the tail of the adult" [MGI:anna]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr