ENSDARG00000002971


Danio rerio

Features
Gene ID: ENSDARG00000002971
  
Biological name :phc1
  
Synonyms : phc1 / polyhomeotic homolog 1
  
Possible biological names infered from orthology : Mus musculus polyhomeotic 1 (Phc1), transcript variant 5, mRNA. / P78364
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 31942527
Gene end: 31960652
  
Corresponding Affymetrix probe sets: Dr.19425.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000151459
Ensembl peptide - ENSDARP00000058495
Ensembl peptide - ENSDARP00000152817
NCBI entrez gene - 403008     See in Manteia.
RefSeq - XM_005158338
swissprot - E7F4T8
ZFIN ID - ZDB-GENE-081022-39
Ensembl - ENSDARG00000002971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PHC1ENSGALG00000014263Gallus gallus
 PHC1ENSG00000111752Homo sapiens
 Phc1ENSMUSG00000040669Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
phc2b / polyhomeotic homolog 2b (Drosophila) / PHC2* / Q8IXK0* / Q9QWH1* / polyhomeotic homolog 2* / Polyhomeotic-like protein 2 *ENSDARG0000001322426
si:ch211-230g15.5ENSDARG0000007916718
phc2a / Q8QHL5 / polyhomeotic homolog 2a (Drosophila) / PHC2* / Q8IXK0* / Q9QWH1* / polyhomeotic homolog 2* / Polyhomeotic-like protein 2 *ENSDARG0000005669512
samd11 / sterile alpha motif domain containing 11 / Q1RNF8* / Q96NU1* / Sterile alpha motif domain-containing protein 11 *ENSDARG0000007785210
samd7 / sterile alpha motif domain containing 7 / Q7Z3H4* / Q8C8Y5* / Sterile alpha motif domain-containing protein 7 *ENSDARG000000603546


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR012313  Zinc finger, FCS-type
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0008270 zinc ion binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006010 bmi1a / bmi1 polycomb ring finger oncogene 1a / BMI1* / P35226* / P25916* / COMMD3-BMI1* / COMMD3-BMI1 readthrough* / Polycomb complex protein BMI-1 * / BMI1 proto-oncogene, polycomb ring finger*  / complex
 ENSDARG00000037773 rybpa / RING1 and YY1 binding protein a / RYBP* / Q8CCI5* / Q8N488* / RING1 and YY1 binding protein*  / complex
 ENSDARG00000013076 bmi1b / Q7T3E6 / bmi1 polycomb ring finger oncogene 1b / BMI1* / P25916* / P35226* / COMMD3-BMI1* / COMMD3-BMI1 readthrough* / Polycomb complex protein BMI-1 * / BMI1 proto-oncogene, polyco...  / complex






 

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