ENSMUSG00000040950


Mus musculus

Features
Gene ID: ENSMUSG00000040950
  
Biological name :Mgl2
  
Synonyms : Mgl2
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 70130329
Gene end: 70137550
  
Corresponding Affymetrix probe sets: 10377774 (MoGene1.0st)   1438467_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048568
Ensembl peptide - ENSMUSP00000104225
Ensembl peptide - ENSMUSP00000131344
NCBI entrez gene - 216864     See in Manteia.
MGI - MGI:2385729
RefSeq - XM_017314459
RefSeq - XM_006532912
RefSeq - XM_006532913
RefSeq - XM_006532914
RefSeq - XM_006532915
RefSeq - NM_145137
RefSeq Peptide - NP_660119
swissprot - F6QSC4
swissprot - A9XX86
swissprot - Q8JZN1
Ensembl - ENSMUSG00000040950
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-283g2.2ENSDARG00000108953Danio rerio
 si:ch211-283g2.3ENSDARG00000046092Danio rerio
 si:ch73-361h17.1ENSDARG00000095963Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P49300 / Clec10a / C-type lectin domain family 10 member A ENSMUSG0000000031881
Asgr1 / P34927 / Asialoglycoprotein receptor 1 / P07306*ENSMUSG0000002088445
Asgr2 / P24721 / Asialoglycoprotein receptor 2 / P07307*ENSMUSG0000004096336
Clec4f / Q8N1N0* / C-type lectin domain family 4 member F*ENSMUSG0000001454223
Q91ZX1 / Cd209a / CD209 antigen-like protein A / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149421
Q91ZW7 / Cd209e / CD209 antigen-like protein E / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004019721
P20693 / Fcer2a / Low affinity immunoglobulin epsilon Fc receptor / FCER2* / P06734* / Fc fragment of IgE receptor II*ENSMUSG0000000554020
Clec4g / Q8BNX1 / C-type lectin domain family 4 member G / Q6UXB4*ENSMUSG0000007449120
Q91ZW8 / Cd209d / CD209 antigen-like protein D / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149520
Q8CJ91 / Cd209b / CD209 antigen-like protein B / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000006598719
Cd209f / CD209f antigenENSMUSG0000005190619
Clec4e / Q9R0Q8 / C-type lectin domain family 4 member E / Q9ULY5*ENSMUSG0000003014218
Cd207 / Q8VBX4 / C-type lectin domain family 4 member K / Q9UJ71* / CD207 molecule*ENSMUSG0000003478318
Q91ZW9 / Cd209c / CD209 antigen-like protein C / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004016517
Cd209g / CD209g antigenENSMUSG0000007916816


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030246 carbohydrate binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000701 abnormal lymph node size "deviation from the normal lymph node size " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0002434 abnormal T helper 2 morphology/development "anomalous structure, formation, or numbers of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses. These cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mc1rtm1.1(KOMP)Vlcg/Mc1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Mc1rtm1.1(KOMP)Vlcg/Ucd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0008119 decreased Langerhans cell number "reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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