ENSMUSG00000020884


Mus musculus

Features
Gene ID: ENSMUSG00000020884
  
Biological name :Asgr1
  
Synonyms : Asgr1 / Asialoglycoprotein receptor 1 / P34927
  
Possible biological names infered from orthology : P07306
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 70054085
Gene end: 70057894
  
Corresponding Affymetrix probe sets: 10377751 (MoGene1.0st)   1421944_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137469
Ensembl peptide - ENSMUSP00000018699
Ensembl peptide - ENSMUSP00000090637
Ensembl peptide - ENSMUSP00000104226
Ensembl peptide - ENSMUSP00000121842
NCBI entrez gene - 11889     See in Manteia.
MGI - MGI:88081
RefSeq - NM_009714
RefSeq - XM_017314231
RefSeq - NM_001291131
RefSeq - NM_001291132
RefSeq Peptide - NP_001278060
RefSeq Peptide - NP_001278061
RefSeq Peptide - NP_033844
swissprot - B1AR34
swissprot - J3QPT6
swissprot - P34927
Ensembl - ENSMUSG00000020884
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-283g2.2ENSDARG00000108953Danio rerio
 si:ch211-283g2.3ENSDARG00000046092Danio rerio
 si:ch73-361h17.1ENSDARG00000095963Danio rerio
 ASGR1ENSG00000141505Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mgl2ENSMUSG0000004095053
Asgr2 / P24721 / Asialoglycoprotein receptor 2 / P07307*ENSMUSG0000004096351
P49300 / Clec10a / C-type lectin domain family 10 member A ENSMUSG0000000031851
Clec4f / Q8N1N0* / C-type lectin domain family 4 member F*ENSMUSG0000001454226
Clec4g / Q8BNX1 / C-type lectin domain family 4 member G / Q6UXB4*ENSMUSG0000007449124
P20693 / Fcer2a / Low affinity immunoglobulin epsilon Fc receptor / FCER2* / P06734* / Fc fragment of IgE receptor II*ENSMUSG0000000554024
Q8CJ91 / Cd209b / CD209 antigen-like protein B / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000006598723
Cd209f / CD209f antigenENSMUSG0000005190622
Q91ZW8 / Cd209d / CD209 antigen-like protein D / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149521
Q91ZW7 / Cd209e / CD209 antigen-like protein E / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004019721
Q91ZX1 / Cd209a / CD209 antigen-like protein A / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149421
Cd207 / Q8VBX4 / C-type lectin domain family 4 member K / Q9UJ71* / CD207 molecule*ENSMUSG0000003478320
Q91ZW9 / Cd209c / CD209 antigen-like protein C / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004016520
Clec4e / Q9R0Q8 / C-type lectin domain family 4 member E / Q9ULY5*ENSMUSG0000003014220
Cd209g / CD209g antigenENSMUSG0000007916819


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004873 asialoglycoprotein receptor activity IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Asparagine N-linked glycosylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otop1mlh/Otop1mlh
Genetic Background: involves: BALB/cJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mtortm1.1Seq/Mtortm1.2Seq,Tg(Nphs2-cre)1Seq/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005607 decreased bleeding time "less than the normal duration of blood flow after skin puncture; indicative of platement and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040963 Asgr2 / P24721 / Asialoglycoprotein receptor 2 / P07307*  / complex






 

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