ENSMUSG00000030142


Mus musculus

Features
Gene ID: ENSMUSG00000030142
  
Biological name :Clec4e
  
Synonyms : Clec4e / C-type lectin domain family 4 member E / Q9R0Q8
  
Possible biological names infered from orthology : Q9ULY5
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 123281789
Gene end: 123289870
  
Corresponding Affymetrix probe sets: 10547664 (MoGene1.0st)   1420330_at (Mouse Genome 430 2.0 Array)   1420331_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032239
Ensembl peptide - ENSMUSP00000135081
Ensembl peptide - ENSMUSP00000135682
NCBI entrez gene - 56619     See in Manteia.
MGI - MGI:1861232
RefSeq - NM_019948
RefSeq Peptide - NP_064332
swissprot - Q9R0Q8
swissprot - H3BJQ5
swissprot - H3BL75
swissprot - Q4FK29
Ensembl - ENSMUSG00000030142
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01058107.1ENSDARG00000112826Danio rerio
 cd209ENSDARG00000029461Danio rerio
 CR847844.1ENSDARG00000087245Danio rerio
 CR847844.2ENSDARG00000102680Danio rerio
 si:ch211-170d8.8ENSDARG00000090945Danio rerio
 si:ch211-214k5.3ENSDARG00000043894Danio rerio
 si:ch73-111e15.1ENSDARG00000008182Danio rerio
 si:ch73-122g19.1ENSDARG00000069323Danio rerio
 si:dkey-181c13.1ENSDARG00000025150Danio rerio
 si:dkey-187i8.2ENSDARG00000096624Danio rerio
 zmp:0000000924ENSDARG00000088219Danio rerio
 zmp:0000000937ENSDARG00000088727Danio rerio
 CLEC4EENSG00000166523Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91ZX1 / Cd209a / CD209 antigen-like protein A / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149433
P49300 / Clec10a / C-type lectin domain family 10 member A ENSMUSG0000000031829
Clec4f / Q8N1N0* / C-type lectin domain family 4 member F*ENSMUSG0000001454229
Q91ZW8 / Cd209d / CD209 antigen-like protein D / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149529
Cd209g / CD209g antigenENSMUSG0000007916828
Cd209f / CD209f antigenENSMUSG0000005190628
Mgl2ENSMUSG0000004095028
Asgr2 / P24721 / Asialoglycoprotein receptor 2 / P07307*ENSMUSG0000004096327
P20693 / Fcer2a / Low affinity immunoglobulin epsilon Fc receptor / FCER2* / P06734* / Fc fragment of IgE receptor II*ENSMUSG0000000554027
Cd207 / Q8VBX4 / C-type lectin domain family 4 member K / Q9UJ71* / CD207 molecule*ENSMUSG0000003478327
Asgr1 / P34927 / Asialoglycoprotein receptor 1 / P07306*ENSMUSG0000002088427
Q91ZW7 / Cd209e / CD209 antigen-like protein E / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004019726
Clec4g / Q8BNX1 / C-type lectin domain family 4 member G / Q6UXB4*ENSMUSG0000007449126
Q8CJ91 / Cd209b / CD209 antigen-like protein B / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000006598726
Q91ZW9 / Cd209c / CD209 antigen-like protein C / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004016526


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002292 T cell differentiation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006955 immune response IMP
 biological_processGO:0038094 Fc-gamma receptor signaling pathway IDA
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0050715 positive regulation of cytokine secretion IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005398 decreased susceptibility to fungal infection "reduced likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008559 abnormal interferon-gamma secretion "anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008615 decreased circulating interleukin-17 level "reduction in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008680 abnormal interleukin-17 secretion "anomaly in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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