ENSMUSG00000065987


Mus musculus

Features
Gene ID: ENSMUSG00000065987
  
Biological name :Cd209b
  
Synonyms : CD209 antigen-like protein B / Cd209b / Q8CJ91
  
Possible biological names infered from orthology : CD209 / CD209 molecule / CLEC4M / C-type lectin domain family 4 member M / Q9H2X3 / Q9NNX6
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 3917655
Gene end: 3926844
  
Corresponding Affymetrix probe sets: 10576816 (MoGene1.0st)   1426157_a_at (Mouse Genome 430 2.0 Array)   1456895_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081104
Ensembl peptide - ENSMUSP00000106643
Ensembl peptide - ENSMUSP00000126070
Ensembl peptide - ENSMUSP00000140695
NCBI entrez gene - 69165     See in Manteia.
MGI - MGI:1916415
RefSeq - XM_006508870
RefSeq - NM_001037800
RefSeq - NM_001287211
RefSeq - NM_026972
RefSeq Peptide - NP_001274140
RefSeq Peptide - NP_081248
RefSeq Peptide - NP_001032889
swissprot - Q3UTX5
swissprot - Q8CJ85
swissprot - Q8CJ91
Ensembl - ENSMUSG00000065987
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:174904ENSDARG00000059049Danio rerio
 CD209ENSG00000090659Homo sapiens
 CLEC4MENSG00000104938Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91ZW8 / Cd209d / CD209 antigen-like protein D / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149547
Q91ZX1 / Cd209a / CD209 antigen-like protein A / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149441
Q91ZW7 / Cd209e / CD209 antigen-like protein E / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004019738
Q91ZW9 / Cd209c / CD209 antigen-like protein C / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004016532
Cd209f / CD209f antigenENSMUSG0000005190626
Cd209g / CD209g antigenENSMUSG0000007916824
Clec4f / Q8N1N0* / C-type lectin domain family 4 member F*ENSMUSG0000001454221
Mgl2ENSMUSG0000004095020
Asgr1 / P34927 / Asialoglycoprotein receptor 1 / P07306*ENSMUSG0000002088420
Asgr2 / P24721 / Asialoglycoprotein receptor 2 / P07307*ENSMUSG0000004096319
Clec4g / Q8BNX1 / C-type lectin domain family 4 member G / Q6UXB4*ENSMUSG0000007449118
P20693 / Fcer2a / Low affinity immunoglobulin epsilon Fc receptor / FCER2* / P06734* / Fc fragment of IgE receptor II*ENSMUSG0000000554018
P49300 / Clec10a / C-type lectin domain family 10 member A ENSMUSG0000000031818
Cd207 / Q8VBX4 / C-type lectin domain family 4 member K / Q9UJ71* / CD207 molecule*ENSMUSG0000003478318
Clec4e / Q9R0Q8 / C-type lectin domain family 4 member E / Q9ULY5*ENSMUSG0000003014217


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001879 detection of yeast IDA
 biological_processGO:0006897 endocytosis IDA
 biological_processGO:0006910 phagocytosis, recognition IDA
 biological_processGO:0016045 detection of bacterium IDA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IDA
 biological_processGO:0050766 positive regulation of phagocytosis IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 molecular_functionGO:0001872 (1->3)-beta-D-glucan binding IDA
 molecular_functionGO:0005537 mannose binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0030247 polysaccharide binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
CD209 (DC-SIGN) signaling
Butyrophilin (BTN) family interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nppatm1Unc/Nppa+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nppatm1Unc/Nppa+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nppatm1Unc/Nppa+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005635 decreased circulating bilirubin level "less thant the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nppatm1Unc/Nppa+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cd209btm1Anjm/Cd209btm1Anjm
Genetic Background: B6.129P2-Cd209btm1Anjm

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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