ENSMUSG00000031494


Mus musculus

Features
Gene ID: ENSMUSG00000031494
  
Biological name :Cd209a
  
Synonyms : Cd209a / CD209 antigen-like protein A / Q91ZX1
  
Possible biological names infered from orthology : CD209 / CD209 molecule / CLEC4M / C-type lectin domain family 4 member M / Q9H2X3 / Q9NNX6
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 3743397
Gene end: 3748984
  
Corresponding Affymetrix probe sets: 10576784 (MoGene1.0st)   1426172_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146627
Ensembl peptide - ENSMUSP00000146702
Ensembl peptide - ENSMUSP00000012847
NCBI entrez gene - 170786     See in Manteia.
MGI - MGI:2157942
RefSeq - NM_133238
RefSeq Peptide - NP_573501
swissprot - A0A140LI09
swissprot - Q91ZX1
Ensembl - ENSMUSG00000031494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:174904ENSDARG00000059049Danio rerio
 CD209ENSG00000090659Homo sapiens
 CLEC4MENSG00000104938Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91ZW8 / Cd209d / CD209 antigen-like protein D / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149555
Q8CJ91 / Cd209b / CD209 antigen-like protein B / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000006598755
Q91ZW7 / Cd209e / CD209 antigen-like protein E / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004019752
Q91ZW9 / Cd209c / CD209 antigen-like protein C / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004016545
Cd209f / CD209f antigenENSMUSG0000005190638
Cd209g / CD209g antigenENSMUSG0000007916832
Clec4e / Q9R0Q8 / C-type lectin domain family 4 member E / Q9ULY5*ENSMUSG0000003014229
Mgl2ENSMUSG0000004095029
P49300 / Clec10a / C-type lectin domain family 10 member A ENSMUSG0000000031828
Clec4f / Q8N1N0* / C-type lectin domain family 4 member F*ENSMUSG0000001454226
Asgr1 / P34927 / Asialoglycoprotein receptor 1 / P07306*ENSMUSG0000002088425
P20693 / Fcer2a / Low affinity immunoglobulin epsilon Fc receptor / FCER2* / P06734* / Fc fragment of IgE receptor II*ENSMUSG0000000554025
Asgr2 / P24721 / Asialoglycoprotein receptor 2 / P07307*ENSMUSG0000004096325
Clec4g / Q8BNX1 / C-type lectin domain family 4 member G / Q6UXB4*ENSMUSG0000007449125
Cd207 / Q8VBX4 / C-type lectin domain family 4 member K / Q9UJ71* / CD207 molecule*ENSMUSG0000003478322


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0042129 regulation of T cell proliferation ISO
 biological_processGO:0046718 viral entry into host cell IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 molecular_functionGO:0001618 virus receptor activity ISO
 molecular_functionGO:0005537 mannose binding IEA
 molecular_functionGO:0030246 carbohydrate binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding ISO
 molecular_functionGO:0097367 carbohydrate derivative binding IDA


Pathways (from Reactome)
Pathway description
CD209 (DC-SIGN) signaling
Butyrophilin (BTN) family interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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