Manteia - Molecule gene

ENSMUSG00000040963

Mus musculus

Features

Gene ID:	ENSMUSG00000040963

Biological name :	Asgr2

Synonyms :	Asgr2 / Asialoglycoprotein receptor 2 / P24721

Possible biological names infered from orthology :	P07307

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	B3
Gene start:	70092644
Gene end:	70106187

Corresponding Affymetrix probe sets:	10377763 (MoGene1.0st) 1419747_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000099632 Ensembl peptide - ENSMUSP00000121189 Ensembl peptide - ENSMUSP00000136505 NCBI entrez gene - 11890 See in Manteia. MGI - MGI:88082 RefSeq - NM_001313926 RefSeq - NM_001313925 RefSeq - NM_001313927 RefSeq - NM_007493 RefSeq Peptide - NP_001300855 RefSeq Peptide - NP_001300854 RefSeq Peptide - NP_031519 RefSeq Peptide - NP_001300856 swissprot - P24721 swissprot - J3QMY0 swissprot - B1AR35 Ensembl - ENSMUSG00000040963

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
si:ch211-283g2.2	ENSDARG00000108953	Danio rerio
si:ch211-283g2.3	ENSDARG00000046092	Danio rerio
si:ch73-361h17.1	ENSDARG00000095963	Danio rerio
ASGR2	ENSG00000161944	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Asgr1 / P34927 / Asialoglycoprotein receptor 1 / P07306*	ENSMUSG00000020884	48
P49300 / Clec10a / C-type lectin domain family 10 member A	ENSMUSG00000000318	41
Mgl2	ENSMUSG00000040950	40
Clec4f / Q8N1N0* / C-type lectin domain family 4 member F*	ENSMUSG00000014542	26
Clec4g / Q8BNX1 / C-type lectin domain family 4 member G / Q6UXB4*	ENSMUSG00000074491	23
P20693 / Fcer2a / Low affinity immunoglobulin epsilon Fc receptor / FCER2* / P06734* / Fc fragment of IgE receptor II*	ENSMUSG00000005540	23
Cd209f / CD209f antigen	ENSMUSG00000051906	22
Q91ZW8 / Cd209d / CD209 antigen-like protein D / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*	ENSMUSG00000031495	20
Q8CJ91 / Cd209b / CD209 antigen-like protein B / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*	ENSMUSG00000065987	20
Q91ZX1 / Cd209a / CD209 antigen-like protein A / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*	ENSMUSG00000031494	20
Cd207 / Q8VBX4 / C-type lectin domain family 4 member K / Q9UJ71* / CD207 molecule*	ENSMUSG00000034783	20
Q91ZW7 / Cd209e / CD209 antigen-like protein E / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*	ENSMUSG00000040197	19
Cd209g / CD209g antigen	ENSMUSG00000079168	19
Clec4e / Q9R0Q8 / C-type lectin domain family 4 member E / Q9ULY5*	ENSMUSG00000030142	19
Q91ZW9 / Cd209c / CD209 antigen-like protein C / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*	ENSMUSG00000040165	17

Protein motifs (from Interpro)

Interpro ID	Name
IPR001304	C-type lectin-like
IPR016186	C-type lectin-like/link domain superfamily
IPR016187	C-type lectin fold
IPR018378	C-type lectin, conserved site
IPR033989	CD209-like, C-type lectin-like domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006897	endocytosis	IEA
biological_process	GO:0009100	glycoprotein metabolic process	IMP
biological_process	GO:0030282	bone mineralization	IEA
biological_process	GO:0031647	regulation of protein stability	IMP
biological_process	GO:0055088	lipid homeostasis	IMP
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0044322	endoplasmic reticulum quality control compartment	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IEA
molecular_function	GO:0030246	carbohydrate binding	IEA

Pathways (from Reactome)

Pathway description

Asparagine N-linked glycosylation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001764	abnormal homeostasis	"anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Traf2^tm1Mak/Traf2^tm1Mak Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J Allelic Composition: Asgr2^tm1Her/Asgr2⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Asgr2^tm1Her/Asgr2⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnnt2^tm2Mmto/Tnnt2⁺ Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002551	abnormal blood coagulation	"altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnnt2^tm2Mmto/Tnnt2⁺ Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnnt2^tm2Mmto/Tnnt2⁺ Genetic Background: involves: 129S/SvEv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020884	Asgr1 / P34927 / Asialoglycoprotein receptor 1 / P07306*	/ complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr