ENSMUSG00000042216


Mus musculus

Features
Gene ID: ENSMUSG00000042216
  
Biological name :Sgsm1
  
Synonyms : Q8BPQ7 / Sgsm1 / Small G protein signaling modulator 1
  
Possible biological names infered from orthology : Q2NKQ1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 113243220
Gene end: 113310786
  
Corresponding Affymetrix probe sets: 10532680 (MoGene1.0st)   1429820_at (Mouse Genome 430 2.0 Array)   1443529_at (Mouse Genome 430 2.0 Array)   1447979_at (Mouse Genome 430 2.0 Array)   1447980_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114932
Ensembl peptide - ENSMUSP00000046544
Ensembl peptide - ENSMUSP00000084106
Ensembl peptide - ENSMUSP00000107943
Ensembl peptide - ENSMUSP00000107944
NCBI entrez gene - 52850     See in Manteia.
MGI - MGI:107320
RefSeq - XM_006535122
RefSeq - NM_001162965
RefSeq - NM_001254731
RefSeq - NM_001309526
RefSeq - NM_001309528
RefSeq - NM_172718
RefSeq Peptide - NP_766306
RefSeq Peptide - NP_001156437
RefSeq Peptide - NP_001241660
RefSeq Peptide - NP_001296455
RefSeq Peptide - NP_001296457
swissprot - D3Z7V5
swissprot - Q8BPQ7
swissprot - B2RQR5
swissprot - D3Z7V4
swissprot - D3YUT7
Ensembl - ENSMUSG00000042216
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgsm1aENSDARG00000028857Danio rerio
 sgsm1bENSDARG00000075376Danio rerio
 SGSM1ENSGALG00000005379Gallus gallus
 SGSM1ENSG00000167037Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgsm2 / Q80U12 / Small G protein signaling modulator 2 / O43147*ENSMUSG0000003835159
Tbc1d16 / Mus musculus TBC1 domain family, member 16 (Tbc1d16), transcript variant 2, mRNA. / Q8TBP0* / TBC1 domain family member 16*ENSMUSG0000003997613
Q9CXF4 / Tbc1d15 / TBC1 domain family member 15 / Q8TC07*ENSMUSG0000002013012
A1A5B6 / Tbc1d25 / TBC1 domain family member 25 / Q3MII6*ENSMUSG0000003920112
Q8BYH7 / Tbc1d17 / TBC1 domain family, member 17 / Q9HA65*ENSMUSG0000003852012


Protein motifs (from Interpro)
Interpro ID Name
 IPR000195  Rab-GTPase-TBC domain
 IPR004012  RUN domain
 IPR035969  Rab-GTPase-TBC domain superfamily
 IPR037213  RUN domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0031338 regulation of vesicle fusion IBA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0090630 activation of GTPase activity IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0012505 endomembrane system IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017137 Rab GTPase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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