ENSMUSG00000043535


Mus musculus

Features
Gene ID: ENSMUSG00000043535
  
Biological name :Setx
  
Synonyms : A2AKX3 / Probable helicase senataxin / Setx
  
Possible biological names infered from orthology : Q7Z333 / senataxin
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 29124181
Gene end: 29182471
  
Corresponding Affymetrix probe sets: 10470665 (MoGene1.0st)   1433794_at (Mouse Genome 430 2.0 Array)   1440459_at (Mouse Genome 430 2.0 Array)   1458080_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119176
Ensembl peptide - ENSMUSP00000119521
Ensembl peptide - ENSMUSP00000051492
NCBI entrez gene - 269254     See in Manteia.
MGI - MGI:2443480
RefSeq - XM_011239106
RefSeq - XM_006498079
RefSeq - XM_006498080
RefSeq - XM_006498082
RefSeq - XM_011239105
RefSeq - NM_198033
RefSeq Peptide - NP_932150
swissprot - F6R186
swissprot - A0A0A0MQJ0
swissprot - A2AKX3
Ensembl - ENSMUSG00000043535
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 setxENSDARG00000022996Danio rerio
 SETXENSGALG00000003661Gallus gallus
 SETXENSG00000107290Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Znfx1 / Q8R151 / zinc finger, NFX1-type containing 1 / Q9P2E3*ENSMUSG000000395019
Aqr / Q8CFQ3 / Intron-binding protein aquarius / O60306* / aquarius intron-binding spliceosomal factor*ENSMUSG000000403838


Protein motifs (from Interpro)
Interpro ID Name
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006353 DNA-templated transcription, termination IEA
 biological_processGO:0006369 termination of RNA polymerase II transcription IMP
 biological_processGO:0006376 mRNA splice site selection IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007623 circadian rhythm IMP
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0033120 positive regulation of RNA splicing IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0060566 positive regulation of DNA-templated transcription, termination IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:2000144 positive regulation of DNA-templated transcription, initiation IEA
 biological_processGO:2000806 positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled IEA
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0030426 growth cone ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045171 intercellular bridge IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001147 transcription termination site sequence-specific DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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