ENSMUSG00000046879


Mus musculus

Features
Gene ID: ENSMUSG00000046879
  
Biological name :Irgm1
  
Synonyms : Irgm1 / Mus musculus immunity-related GTPase family M member 1 (Irgm1), transcript variant 2, mRNA. / Q60766
  
Possible biological names infered from orthology : A1A4Y4 / immunity related GTPase M / IRGM
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.2
Gene start: 48861968
Gene end: 48871683
  
Corresponding Affymetrix probe sets: 10385500 (MoGene1.0st)   1418825_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050446
Ensembl peptide - ENSMUSP00000094870
NCBI entrez gene - 15944     See in Manteia.
MGI - MGI:107567
RefSeq - XM_011248764
RefSeq - NM_001355757
RefSeq - NM_008326
RefSeq - XM_006532305
RefSeq Peptide - NP_032352
RefSeq Peptide - NP_001342686
swissprot - Q60766
swissprot - J7NUP1
Ensembl - ENSMUSG00000046879
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irgq2ENSDARG00000068657Danio rerio
 IRGMENSG00000237693Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igtp / IRGM* / A1A4Y4* / immunity related GTPase M*ENSMUSG0000007885346
Irgm2 / IRGM* / A1A4Y4* / immunity related GTPase M*ENSMUSG0000006987444
Gm5431ENSMUSG0000005816330
Gm12185ENSMUSG0000004885230
9930111J21Rik1 / RIKEN cDNA 9930111J21 gene 1ENSMUSG0000006989330
Ifi47ENSMUSG0000007892029
Tgtp1 / Q3T9E4 / Q62293 / T-cell-specific guanine nucleotide triphosphate-binding protein 1 ENSMUSG0000007892229
9930111J21Rik2 / RIKEN cDNA 9930111J21 gene 2ENSMUSG0000006989229
Tgtp2 / Q3T9E4 / Q62293 / T-cell-specific guanine nucleotide triphosphate-binding protein 1 ENSMUSG0000007892129
Iigp1 / Q9QZ85 / Interferon-inducible GTPase 1 ENSMUSG0000005407228
Gm4841ENSMUSG0000006860628
Gm4951ENSMUSG0000007355528
F830016B08RikENSMUSG0000009094226
Irgc1 / Mus musculus immunity-related GTPase family, cinema 1 (Irgc1), transcript variant 1, mRNA. / IRGC* / Q6NXR0* / immunity related GTPase cinema*ENSMUSG0000006202825


Protein motifs (from Interpro)
Interpro ID Name
 IPR007743  Immunity-related GTPases-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030385  IRG-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006952 defense response IMP
 biological_processGO:0035458 cellular response to interferon-beta IBA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IMP
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0075044 autophagy of host cells involved in interaction with symbiont IMP
 biological_processGO:1901098 positive regulation of autophagosome maturation IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000421 autophagosome membrane IEA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005776 autophagosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044754 autolysosome IDA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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