ENSMUSG00000069874


Mus musculus

Features
Gene ID: ENSMUSG00000069874
  
Biological name :Irgm2
  
Synonyms : Irgm2
  
Possible biological names infered from orthology : A1A4Y4 / immunity related GTPase M / IRGM
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 58199618
Gene end: 58222782
  
Corresponding Affymetrix probe sets: 10376326 (MoGene1.0st)   1417793_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104464
Ensembl peptide - ENSMUSP00000146805
Ensembl peptide - ENSMUSP00000056001
NCBI entrez gene - 54396     See in Manteia.
MGI - MGI:1926262
RefSeq - NM_019440
RefSeq Peptide - NP_062313
swissprot - A0A140LIF8
swissprot - Q9Z1M2
Ensembl - ENSMUSG00000069874
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irgq2ENSDARG00000068657Danio rerio
 IRGMENSG00000237693Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igtp / IRGM* / A1A4Y4* / immunity related GTPase M*ENSMUSG0000007885351
Irgm1 / Q60766 / Mus musculus immunity-related GTPase family M member 1 (Irgm1), transcript variant 2, mRNA. / IRGM* / A1A4Y4* / immunity related GTPase M*ENSMUSG0000004687946
Gm12185ENSMUSG0000004885230
9930111J21Rik1 / RIKEN cDNA 9930111J21 gene 1ENSMUSG0000006989330
Tgtp1 / Q3T9E4 / Q62293 / T-cell-specific guanine nucleotide triphosphate-binding protein 1 ENSMUSG0000007892229
Gm5431ENSMUSG0000005816329
Tgtp2 / Q3T9E4 / Q62293 / T-cell-specific guanine nucleotide triphosphate-binding protein 1 ENSMUSG0000007892129
9930111J21Rik2 / RIKEN cDNA 9930111J21 gene 2ENSMUSG0000006989228
Ifi47ENSMUSG0000007892028
Gm4841ENSMUSG0000006860627
F830016B08RikENSMUSG0000009094227
Gm4951ENSMUSG0000007355527
Irgc1 / Mus musculus immunity-related GTPase family, cinema 1 (Irgc1), transcript variant 1, mRNA. / IRGC* / Q6NXR0* / immunity related GTPase cinema*ENSMUSG0000006202826
Iigp1 / Q9QZ85 / Interferon-inducible GTPase 1 ENSMUSG0000005407226


Protein motifs (from Interpro)
Interpro ID Name
 IPR007743  Immunity-related GTPases-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030385  IRG-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly ISO
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0010508 positive regulation of autophagy ISO
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation ISO
 biological_processGO:0031648 protein destabilization ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0034341 response to interferon-gamma IMP
 biological_processGO:0035458 cellular response to interferon-beta IBA
 biological_processGO:0042742 defense response to bacterium ISO
 biological_processGO:0042832 defense response to protozoan IDA
 biological_processGO:0043254 regulation of protein complex assembly ISO
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0050829 defense response to Gram-negative bacterium ISO
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway ISO
 biological_processGO:0061635 regulation of protein complex stability ISO
 biological_processGO:0061739 protein lipidation involved in autophagosome assembly ISO
 biological_processGO:0061762 CAMKK-AMPK signaling cascade ISO
 biological_processGO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
 biological_processGO:0071222 cellular response to lipopolysaccharide ISO
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity ISO
 biological_processGO:0075044 autophagy of host cells involved in interaction with symbiont ISO
 biological_processGO:0098586 cellular response to virus ISO
 biological_processGO:1901098 positive regulation of autophagosome maturation ISO
 cellular_componentGO:0000139 Golgi membrane ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0020003 symbiont-containing vacuole IDA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity ISO
 molecular_functionGO:0050700 CARD domain binding ISO
 molecular_functionGO:0051434 BH3 domain binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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