ENSMUSG00000078853


Mus musculus

Features
Gene ID: ENSMUSG00000078853
  
Biological name :Igtp
  
Synonyms : Igtp
  
Possible biological names infered from orthology : A1A4Y4 / immunity related GTPase M / IRGM
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 58199556
Gene end: 58207591
  
Corresponding Affymetrix probe sets: 1417141_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047356
Ensembl peptide - ENSMUSP00000130878
Ensembl peptide - ENSMUSP00000091721
NCBI entrez gene - 16145     See in Manteia.
MGI - MGI:107729
RefSeq - NM_018738
RefSeq Peptide - NP_061208
swissprot - E9Q9N8
swissprot - E9PW35
swissprot - Q9DCE9
Ensembl - ENSMUSG00000078853
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irgq2ENSDARG00000068657Danio rerio
 IRGMENSG00000237693Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irgm2 / IRGM* / A1A4Y4* / immunity related GTPase M*ENSMUSG0000006987448
Irgm1 / Q60766 / Mus musculus immunity-related GTPase family M member 1 (Irgm1), transcript variant 2, mRNA. / IRGM* / A1A4Y4* / immunity related GTPase M*ENSMUSG0000004687944
9930111J21Rik1 / RIKEN cDNA 9930111J21 gene 1ENSMUSG0000006989328
Gm5431ENSMUSG0000005816328
Gm12185ENSMUSG0000004885228
Ifi47ENSMUSG0000007892027
Irgc1 / Mus musculus immunity-related GTPase family, cinema 1 (Irgc1), transcript variant 1, mRNA. / IRGC* / Q6NXR0* / immunity related GTPase cinema*ENSMUSG0000006202827
Gm4951ENSMUSG0000007355526
Tgtp2 / Q3T9E4 / Q62293 / T-cell-specific guanine nucleotide triphosphate-binding protein 1 ENSMUSG0000007892125
9930111J21Rik2 / RIKEN cDNA 9930111J21 gene 2ENSMUSG0000006989225
F830016B08RikENSMUSG0000009094225
Iigp1 / Q9QZ85 / Interferon-inducible GTPase 1 ENSMUSG0000005407225
Gm4841ENSMUSG0000006860625
Tgtp1 / Q3T9E4 / Q62293 / T-cell-specific guanine nucleotide triphosphate-binding protein 1 ENSMUSG0000007892225


Protein motifs (from Interpro)
Interpro ID Name
 IPR007743  Immunity-related GTPases-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030385  IRG-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006952 defense response IBA
 biological_processGO:0035458 cellular response to interferon-beta IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0008647 increased circulating interleukin-12b level "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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