ENSMUSG00000055067


Mus musculus

Features
Gene ID: ENSMUSG00000055067
  
Biological name :Smyd3
  
Synonyms : Histone-lysine N-methyltransferase SMYD3 / Q9CWR2 / Smyd3
  
Possible biological names infered from orthology : Q9H7B4 / SET and MYND domain containing 3
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H4
Gene start: 178951960
Gene end: 179518041
  
Corresponding Affymetrix probe sets: 10360563 (MoGene1.0st)   1442110_at (Mouse Genome 430 2.0 Array)   1452817_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106764
Ensembl peptide - ENSMUSP00000141631
Ensembl peptide - ENSMUSP00000117410
NCBI entrez gene - 69726     See in Manteia.
MGI - MGI:1916976
RefSeq - NM_027188
RefSeq - XM_011238864
RefSeq Peptide - NP_081464
swissprot - D3YZ17
swissprot - Q9CWR2
swissprot - A0A0A6YWP2
Ensembl - ENSMUSG00000055067
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smyd3ENSDARG00000058050Danio rerio
 SMYD3ENSGALG00000010653Gallus gallus
 SMYD3ENSG00000185420Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smyd1 / P97443 / SET and MYND domain containing 1 / Q8NB12*ENSMUSG0000005502730
Smyd2 / Q8R5A0 / N-lysine methyltransferase SMYD2 / Q9NRG4* / SET and MYND domain containing 2*ENSMUSG0000002660330


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR002893  Zinc finger, MYND-type
 IPR025805  Histone-lysine N-methyltransferase Smyd3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006334 nucleosome assembly IMP
 biological_processGO:0006469 negative regulation of protein kinase activity IMP
 biological_processGO:0014904 myotube cell development IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0071549 cellular response to dexamethasone stimulus IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000993 RNA polymerase II core binding IDA
 molecular_functionGO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sirt2tm1a(EUCOMM)Wtsi/Sirt2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr