ENSMUSG00000026603


Mus musculus

Features
Gene ID: ENSMUSG00000026603
  
Biological name :Smyd2
  
Synonyms : N-lysine methyltransferase SMYD2 / Q8R5A0 / Smyd2
  
Possible biological names infered from orthology : Q9NRG4 / SET and MYND domain containing 2
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 189880492
Gene end: 189922363
  
Corresponding Affymetrix probe sets: 10361007 (MoGene1.0st)   1424760_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027897
NCBI entrez gene - 226830     See in Manteia.
MGI - MGI:1915889
RefSeq - XM_017320186
RefSeq - NM_026796
RefSeq - XM_006497146
RefSeq Peptide - NP_081072
swissprot - Q8R5A0
Ensembl - ENSMUSG00000026603
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5RGL7ENSDARG00000005629Danio rerio
 smyd2aENSDARG00000055151Danio rerio
 SMYD2ENSGALG00000009788Gallus gallus
 SMYD2ENSG00000143499Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smyd3 / Q9CWR2 / Histone-lysine N-methyltransferase SMYD3 / Q9H7B4* / SET and MYND domain containing 3*ENSMUSG0000005506730
Smyd1 / P97443 / SET and MYND domain containing 1 / Q8NB12*ENSMUSG0000005502730


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR002893  Zinc finger, MYND-type
 IPR011990  Tetratricopeptide-like helical domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010452 histone H3-K36 methylation IEA
 biological_processGO:0016571 histone methylation IDA
 biological_processGO:0018026 peptidyl-lysine monomethylation IEA
 biological_processGO:0018027 peptidyl-lysine dimethylation IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IDA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046975 histone methyltransferase activity (H3-K36 specific) IDA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
Regulation of TP53 Activity through Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction






 

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