ENSDARG00000005629


Danio rerio

Features
Gene ID: ENSDARG00000005629
  
Biological name :smyd2b
  
Synonyms : Q5RGL7 / SET and MYND domain containing 2b / smyd2b
  
Possible biological names infered from orthology : N-lysine methyltransferase SMYD2 / Q8R5A0 / Q9NRG4 / SET and MYND domain containing 2 / SMYD2
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 572037
Gene end: 592746
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133013
Ensembl peptide - ENSDARP00000005268
Ensembl peptide - ENSDARP00000036459
Ensembl peptide - ENSDARP00000127036
NCBI entrez gene - 568616     See in Manteia.
RefSeq - NM_001045291
RefSeq Peptide - NP_001038756
swissprot - A0A0R4IGJ5
swissprot - Q5RGL7
swissprot - R4GEX3
swissprot - T1ECS2
ZFIN ID - ZDB-GENE-041001-201
Ensembl - ENSDARG00000005629
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMYD2ENSGALG00000009788Gallus gallus
 SMYD2ENSG00000143499Homo sapiens
 Smyd2ENSMUSG00000026603Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smyd2a / SET and MYND domain containing 2a / SMYD2* / Q8R5A0* / Q9NRG4* / SET and MYND domain containing 2* / N-lysine methyltransferase SMYD2 *ENSDARG0000005515159
smyd3 / SET and MYND domain containing 3 / Q9CWR2* / Q9H7B4* / Histone-lysine N-methyltransferase SMYD3 *ENSDARG0000005805029
smyd1b / SET and MYND domain containing 1b / SMYD1* / P97443* / Q8NB12* / SET and MYND domain containing 1*ENSDARG0000009125327
smyd1a / SET and MYND domain containing 1a / SMYD1* / P97443* / Q8NB12* / SET and MYND domain containing 1*ENSDARG0000000928027


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR002893  Zinc finger, MYND-type
 IPR011990  Tetratricopeptide-like helical domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0010452 histone H3-K36 methylation IEA
 biological_processGO:0018026 peptidyl-lysine monomethylation ISS
 biological_processGO:0018027 peptidyl-lysine dimethylation ISS
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator ISS
 biological_processGO:0060047 heart contraction IGI
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISS
 molecular_functionGO:0000993 RNA polymerase II core binding ISS
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046975 histone methyltransferase activity (H3-K36 specific) ISS


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / reaction






 

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