ENSG00000143499


Homo sapiens

Features
Gene ID: ENSG00000143499
  
Biological name :SMYD2
  
Synonyms : Q9NRG4 / SET and MYND domain containing 2 / SMYD2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.3
Gene start: 214281102
Gene end: 214337131
  
Corresponding Affymetrix probe sets: 212921_at (Human Genome U133 Plus 2.0 Array)   212922_s_at (Human Genome U133 Plus 2.0 Array)   243288_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355924
Ensembl peptide - ENSP00000409822
NCBI entrez gene - 56950     See in Manteia.
OMIM - 610663
RefSeq - NM_020197
RefSeq Peptide - NP_064582
swissprot - B0R0U3
swissprot - Q9NRG4
Ensembl - ENSG00000143499
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5RGL7ENSDARG00000005629Danio rerio
 smyd2aENSDARG00000055151Danio rerio
 SMYD2ENSGALG00000009788Gallus gallus
 Smyd2ENSMUSG00000026603Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SMYD3 / Q9H7B4 / SET and MYND domain containing 3ENSG0000018542030
SMYD1 / Q8NB12 / SET and MYND domain containing 1ENSG0000011559330


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR002893  Zinc finger, MYND-type
 IPR011990  Tetratricopeptide-like helical domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010452 histone H3-K36 methylation IEA
 biological_processGO:0016571 histone methylation IEA
 biological_processGO:0018026 peptidyl-lysine monomethylation IDA
 biological_processGO:0018027 peptidyl-lysine dimethylation IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISS
 molecular_functionGO:0000993 RNA polymerase II core binding IEA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016278 lysine N-methyltransferase activity TAS
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046975 histone methyltransferase activity (H3-K36 specific) IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
Regulation of TP53 Activity through Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction






 

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