ENSMUSG00000056851


Mus musculus

Features
Gene ID: ENSMUSG00000056851
  
Biological name :Pcbp2
  
Synonyms : Pcbp2 / Poly(rC)-binding protein 2 / Q61990
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 102470539
Gene end: 102500061
  
Corresponding Affymetrix probe sets: 10427241 (MoGene1.0st)   1421743_a_at (Mouse Genome 430 2.0 Array)   1435881_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155848
Ensembl peptide - ENSMUSP00000155789
Ensembl peptide - ENSMUSP00000155825
Ensembl peptide - ENSMUSP00000076294
Ensembl peptide - ENSMUSP00000077509
Ensembl peptide - ENSMUSP00000104466
Ensembl peptide - ENSMUSP00000154930
Ensembl peptide - ENSMUSP00000155016
Ensembl peptide - ENSMUSP00000155038
Ensembl peptide - ENSMUSP00000155051
Ensembl peptide - ENSMUSP00000155072
Ensembl peptide - ENSMUSP00000155096
Ensembl peptide - ENSMUSP00000155124
Ensembl peptide - ENSMUSP00000155219
Ensembl peptide - ENSMUSP00000155240
Ensembl peptide - ENSMUSP00000155292
Ensembl peptide - ENSMUSP00000155430
Ensembl peptide - ENSMUSP00000155431
Ensembl peptide - ENSMUSP00000155440
Ensembl peptide - ENSMUSP00000155548
Ensembl peptide - ENSMUSP00000155569
Ensembl peptide - ENSMUSP00000155631
Ensembl peptide - ENSMUSP00000155638
Ensembl peptide - ENSMUSP00000155654
Ensembl peptide - ENSMUSP00000155730
Ensembl peptide - ENSMUSP00000155784
NCBI entrez gene - 18521     See in Manteia.
MGI - MGI:108202
RefSeq - XM_017316501
RefSeq - NM_001103165
RefSeq - NM_001103166
RefSeq - NM_001174073
RefSeq - NM_011042
RefSeq - XM_011245507
RefSeq - XM_011245508
RefSeq - XM_011245509
RefSeq - XM_017316497
RefSeq - XM_017316498
RefSeq - XM_017316499
RefSeq - XM_017316500
RefSeq - XM_006520582
RefSeq - XM_006520583
RefSeq - XM_006520584
RefSeq - XM_006520585
RefSeq - XM_006520586
RefSeq - XM_011245495
RefSeq - XM_011245496
RefSeq - XM_011245497
RefSeq - XM_011245498
RefSeq - XM_011245499
RefSeq - XM_011245500
RefSeq - XM_011245501
RefSeq - XM_011245502
RefSeq - XM_011245503
RefSeq - XM_011245504
RefSeq - XM_011245505
RefSeq - XM_011245506
RefSeq Peptide - NP_001096635
RefSeq Peptide - NP_001096636
RefSeq Peptide - NP_001167544
RefSeq Peptide - NP_035172
swissprot - Q3TT81
swissprot - Q61990
swissprot - B2M1R7
Ensembl - ENSMUSG00000056851
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:110045ENSDARG00000110961Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcbp1 / P60335 / Poly(rC)-binding protein 1 / Q15365*ENSMUSG0000005169583
Pcbp3 / P57722 / Mus musculus poly(rC) binding protein 3 (Pcbp3), transcript variant 2, mRNA. / P57721* / poly(rC) binding protein 3*ENSMUSG0000000112072
Pcbp4 / poly(rC) binding protein 4 / P57723*ENSMUSG0000002349554
Hnrnpk / P61979 / Heteroous nuclear ribonucleoprotein K / P61978* / heterogeneous nuclear ribonucleoprotein K*ENSMUSG0000002154633
Nova2 / NOVA alternative splicing regulator 2 / Q9UNW9*ENSMUSG0000003041128
Nova1 / Q9JKN6 / RNA-binding protein Nova-1 / P51513* / NOVA alternative splicing regulator 1*ENSMUSG0000002104727


Protein motifs (from Interpro)
Interpro ID Name
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR015946  K homology domain-like, alpha/beta
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0039694 viral RNA genome replication ISO
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050687 negative regulation of defense response to virus ISS
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0075522 IRES-dependent viral translational initiation ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:1990829 C-rich single-stranded DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Pcbp1em2Salr/Pcbp1+,Pcbp2tm1.2Salr/Pcbp2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pcbp1em2Salr/Pcbp1+,Pcbp2tm1.2Salr/Pcbp2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pcbp1em2Salr/Pcbp1+,Pcbp2tm1.2Salr/Pcbp2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011176 abnormal erythroblast morphology "any structural anomaly of the nucleated precursor of erythrocytes" [ISBN:0-683-40008-8]
Show

Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011898 abnormal platelet cell number "anomaly in the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation" [MGI:csmith]
Show

Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0013848 subcutaneous edema "accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]
Show

Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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