ENSMUSG00000051695


Mus musculus

Features
Gene ID: ENSMUSG00000051695
  
Biological name :Pcbp1
  
Synonyms : P60335 / Pcbp1 / Poly(rC)-binding protein 1
  
Possible biological names infered from orthology : Q15365
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 86524492
Gene end: 86526321
  
Corresponding Affymetrix probe sets: 10545917 (MoGene1.0st)   1448642_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054863
NCBI entrez gene - 23983     See in Manteia.
MGI - MGI:1345635
RefSeq - NM_011865
RefSeq Peptide - NP_035995
swissprot - P60335
Ensembl - ENSMUSG00000051695
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:110045ENSDARG00000110961Danio rerio
 ENSGALG00000041030Gallus gallus
 PCBP1ENSG00000169564Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcbp2 / Q61990 / Poly(rC)-binding protein 2 ENSMUSG0000005685184
Pcbp3 / P57722 / Mus musculus poly(rC) binding protein 3 (Pcbp3), transcript variant 2, mRNA. / P57721* / poly(rC) binding protein 3*ENSMUSG0000000112067
Pcbp4 / poly(rC) binding protein 4 / P57723*ENSMUSG0000002349553
Hnrnpk / P61979 / Heteroous nuclear ribonucleoprotein K / P61978* / heterogeneous nuclear ribonucleoprotein K*ENSMUSG0000002154631
Nova2 / NOVA alternative splicing regulator 2 / Q9UNW9*ENSMUSG0000003041128
Nova1 / Q9JKN6 / RNA-binding protein Nova-1 / P51513* / NOVA alternative splicing regulator 1*ENSMUSG0000002104727


Protein motifs (from Interpro)
Interpro ID Name
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006397 mRNA processing TAS
 biological_processGO:0039694 viral RNA genome replication IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008494 translation activator activity TAS
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0098847 sequence-specific single stranded DNA binding IDA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Pcbp1em2Salr/Pcbp1+,Pcbp2tm1.2Salr/Pcbp2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pcbp1em2Salr/Pcbp1+,Pcbp2tm1.2Salr/Pcbp2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pcbp1em2Salr/Pcbp1+,Pcbp2tm1.2Salr/Pcbp2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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