ENSMUSG00000060373


Mus musculus

Features
Gene ID: ENSMUSG00000060373
  
Biological name :Hnrnpc
  
Synonyms : Heteroous nuclear ribonucleoproteins C1/C2 / Hnrnpc / Q9Z204
  
Possible biological names infered from orthology : heterogeneous nuclear ribonucleoprotein C (C1/C2) / P07910
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C2
Gene start: 52073377
Gene end: 52104028
  
Corresponding Affymetrix probe sets: 10419607 (MoGene1.0st)   10608665 (MoGene1.0st)   1418693_at (Mouse Genome 430 2.0 Array)   1458139_at (Mouse Genome 430 2.0 Array)   1460240_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107237
Ensembl peptide - ENSMUSP00000133052
Ensembl peptide - ENSMUSP00000154166
Ensembl peptide - ENSMUSP00000154182
Ensembl peptide - ENSMUSP00000154212
Ensembl peptide - ENSMUSP00000154737
Ensembl peptide - ENSMUSP00000154757
Ensembl peptide - ENSMUSP00000154238
Ensembl peptide - ENSMUSP00000154347
Ensembl peptide - ENSMUSP00000154537
Ensembl peptide - ENSMUSP00000154619
NCBI entrez gene - 15381     See in Manteia.
MGI - MGI:107795
RefSeq - XM_017315859
RefSeq - NM_001170981
RefSeq - NM_001170982
RefSeq - NM_001170983
RefSeq - NM_001170984
RefSeq - NM_016884
RefSeq - XM_017315853
RefSeq - XM_017315854
RefSeq - XM_017315855
RefSeq - XM_017315856
RefSeq - XM_017315857
RefSeq - XM_017315858
RefSeq - XM_006518571
RefSeq - XM_006518572
RefSeq - XM_006518574
RefSeq - XM_006518578
RefSeq - XM_006518581
RefSeq - XM_011244965
RefSeq - XM_017315849
RefSeq - XM_017315850
RefSeq - XM_017315851
RefSeq - XM_017315852
RefSeq Peptide - NP_001164453
RefSeq Peptide - NP_001164454
RefSeq Peptide - NP_001164455
RefSeq Peptide - NP_058580
RefSeq Peptide - NP_001164452
swissprot - Q9Z204
Ensembl - ENSMUSG00000060373
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hnrnpcENSDARG00000053810Danio rerio
 zgc:55733ENSDARG00000103845Danio rerio
 HNRNPCENSG00000092199Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ralyl / Q8BTF8 / RNA-binding Raly-like protein / Q86SE5* / RALY RNA binding protein like*ENSMUSG0000003971748
Raly / Q64012 / hnRNP-associated with lethal yellow / Q9UKM9* / RALY heterogeneous nuclear ribonucleoprotein*ENSMUSG0000002759344


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR017347  Heterogeneous nuclear ribonucleoprotein C
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome ISO
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase ISO
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization ISO
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005681 spliceosomal complex ISS
 cellular_componentGO:0005697 telomerase holoenzyme complex ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0032991 protein-containing complex ISS
 cellular_componentGO:0045120 pronucleus IDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0003730 mRNA 3"-UTR binding ISO
 molecular_functionGO:0008266 poly(U) RNA binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0070034 telomerase RNA binding ISO
 molecular_functionGO:1990247 N6-methyladenosine-containing RNA binding ISO


Pathways (from Reactome)
Pathway description
SUMOylation of RNA binding proteins
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Foxa2tm1Jrt/Foxa2tm1Khk,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Foxa2tm1Jrt/Foxa2tm1Khk,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Hprtb-m3/Y,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Foxa2tm1Jrt/Foxa2tm1Khk,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex






 

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