Manteia - Molecule gene

ENSMUSG00000071054

Mus musculus

Features

Gene ID:	ENSMUSG00000071054

Biological name :	Safb

Synonyms :	D3YXK2 / Safb / Scaffold attachment factor B1

Possible biological names infered from orthology :	Q15424 / scaffold attachment factor B

Species:	Mus musculus

Chr. number:	17
Strand:	1
Band:	D
Gene start:	56584825
Gene end:	56606294

Corresponding Affymetrix probe sets:	10446109 (MoGene1.0st) 1432911_at (Mouse Genome 430 2.0 Array) 1454415_at (Mouse Genome 430 2.0 Array) 1454928_at (Mouse Genome 430 2.0 Array) 1454929_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000092849 Ensembl peptide - ENSMUSP00000138277 Ensembl peptide - ENSMUSP00000138395 Ensembl peptide - ENSMUSP00000138743 NCBI entrez gene - 224903 See in Manteia. MGI - MGI:2146974 RefSeq - XM_017317445 RefSeq - NM_001163300 RefSeq - XM_006524160 RefSeq Peptide - NP_001156772 swissprot - S4R1M2 swissprot - S4R1W0 swissprot - S4R2Q5 swissprot - D3YXK2 Ensembl - ENSMUSG00000071054

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
safb	ENSDARG00000020467	Danio rerio
	ENSGALG00000013365	Gallus gallus
	ENSGALG00000001948	Gallus gallus
SAFB	ENSG00000160633	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Safb2 / Q80YR5 / scaffold attachment factor B2 / Q14151*	ENSMUSG00000042625	62
Sltm / Q8CH25 / SAFB-like, transcription modulator / Q9NWH9*	ENSMUSG00000032212	29

Protein motifs (from Interpro)

Interpro ID	Name
IPR000504	RNA recognition motif domain
IPR003034	SAP domain
IPR034781	Scaffold attachment factor B1
IPR035979	RNA-binding domain superfamily
IPR036361	SAP domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0030520	intracellular estrogen receptor signaling pathway	IMP
biological_process	GO:0040007	growth	IMP
biological_process	GO:0042445	hormone metabolic process	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0050684	regulation of mRNA processing	IEA
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005654	nucleoplasm	IEA
molecular_function	GO:0001047	core promoter binding	IDA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003690	double-stranded DNA binding	IBA
molecular_function	GO:0003723	RNA binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0043565	sequence-specific DNA binding	IBA

Pathways (from Reactome)

Pathway description

SUMOylation of transcription cofactors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001119	abnormal female reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001129	impaired ovarian folliculogenesis	"a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001145	abnormal male reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001152	Leydig cell hyperplasia	"increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001154	seminiferous tubule degeneration	"a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001155	arrest of spermatogenesis	"block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001157	small seminal gland	"reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001380	male reduced copulation without impotence	"males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001929	abnormal gametogenesis	"defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0002161	abnormal fertility/fecundity	"reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6 Allelic Composition: Safb^tm1So/Safb⁺ Genetic Background: involves: 129 * C57BL/6J
MP:0003700	abnormal oviduct transport	"increased or decreased rate of passage of embryos or oocytes from the ovary to the uterus" [J:97633, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0004701	decreased circulating insulin-like growth factor I level	"reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0004833	ovary atrophy	"wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0004901	decreased male germ cell number	"reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0005159	azoospermia	"absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0005181	decreased circulating estradiol level	"less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0005647	abnormal sex gland physiology	"anomalous function of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0008280	male germ cell apoptosis	"presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0009064	oviduct atrophy	"wasting of the oviduct due to injury or disease resulting in reduced size" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0009070	small oviduct	"reduced size of the tube through which the ova pass from the ovary to the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0009546	absent gastric milk in neonates	"failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0010103	small thoracic cage	"reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0010995	abnormal lung alveolus development	"anomaly in the formation of the sacs for holding air in the lungs, which are formed by the terminal dilation of air passageways" [GO:0048286]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Safb^tm1So/Safb⁺ Genetic Background: involves: 129 * C57BL/6J
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6
MP:0013318	abnormal branching involved in seminal vesicle morphogenesis	" anomaly in the process in which the seminal vesicle is generated and organized in many mammals including mice and humans; in mice, the initial seminal vesicle buds form cane-shaped tubes off of the Wolffian ducts before birth; after birth, the initial tubes develop lateral branches that elongate and often undergo secondary branching morphogenesis; branching morphogenesis is largely complete by 2 weeks of age" [MGI:Anna, PMID:16916376]	Show Allelic Composition: Grid2^{tm1(cre/PGR)Ksak}/Grid2^tm2Mim Genetic Background: involves: C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000015120	Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*	/ reaction
ENSMUSG00000020265	Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*	/ reaction
ENSMUSG00000026021	Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*	/ reaction / complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr