ENSDARG00000013575


Danio rerio

Features
Gene ID: ENSDARG00000013575
  
Biological name :rfx2
  
Synonyms : Q5EAP5 / regulatory factor X, 2 (influences HLA class II expression) / rfx2
  
Possible biological names infered from orthology : DNA-binding protein RFX2 / P48378 / P48379 / regulatory factor X2
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 20072987
Gene end: 20138251
  
Corresponding Affymetrix probe sets: Dr.2654.1.A1_at (Zebrafish Array)   Dr.2654.3.S1_a_at (Zebrafish Array)   NM_001013278_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000039332
Ensembl peptide - ENSDARP00000121782
Ensembl peptide - ENSDARP00000113524
Ensembl peptide - ENSDARP00000112969
NCBI entrez gene - 503590     See in Manteia.
RefSeq - NM_001013278
RefSeq Peptide - NP_001013296
swissprot - E9QEW4
swissprot - E9QCU4
swissprot - E9QJ42
swissprot - Q5EAP5
ZFIN ID - ZDB-GENE-050227-4
Ensembl - ENSDARG00000013575
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RFX2ENSGALG00000001773Gallus gallus
 RFX2ENSG00000087903Homo sapiens
 Rfx2ENSMUSG00000024206Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rfx3 / regulatory factor X, 3 (influences HLA class II expression) / P48380* / regulatory factor X3*ENSDARG0000001455065
rfx1a / regulatory factor X, 1a (influences HLA class II expression) / RFX1* / P22670* / P48377* / regulatory factor X1* / MHC class II regulatory factor RFX1 *ENSDARG0000000588354
rfx1b / regulatory factor X, 1b (influences HLA class II expression) / RFX1* / P22670* / P48377* / regulatory factor X1* / MHC class II regulatory factor RFX1 *ENSDARG0000007590449
rfx6 / Q5RJA1 / regulatory factor X, 6 / Q8C7R7* / Q8HWS3* / DNA-binding protein RFX6 *ENSDARG0000004170225
rfx4 / A2BGA0 / regulatory factor X, 4 / Q7TNK1* / Q33E94* / Transcription factor RFX4 *ENSDARG0000002639524
rfx7b / regulatory factor X7b / RFX7* / Q2KHR2* / regulatory factor X7*ENSDARG0000010369114
rfx7a / regulatory factor X7a / RFX7* / Q2KHR2* / regulatory factor X7*ENSDARG0000007723713
rfx5 / regulatory factor X, 5 / P48382* / Q9JL61* / Mus musculus regulatory factor X, 5 (influences HLA class II expression) (Rfx5), transcript variant 2, mRNA.*ENSDARG0000006325810


Protein motifs (from Interpro)
Interpro ID Name
 IPR003150  DNA-binding RFX-type winged-helix domain
 IPR007668  RFX1 transcription activation region
 IPR011991  ArsR-like helix-turn-helix domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0060271 cilium assembly ISS
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased functionality , abnormal
Kupffers vesicle motile cilium decreased length , abnormal
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 ZFA:0000112 gut gut symmetry , abnormal
Show

 ZFA:0000114 heart heart symmetry , abnormal
Show

 ZFA:0000123 liver liver symmetry , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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