ENSDARG00000041702


Danio rerio

Features
Gene ID: ENSDARG00000041702
  
Biological name :rfx6
  
Synonyms : Q5RJA1 / regulatory factor X, 6 / rfx6
  
Possible biological names infered from orthology : DNA-binding protein RFX6 / Q8C7R7 / Q8HWS3
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 42506612
Gene end: 42534504
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000061121
Ensembl peptide - ENSDARP00000116051
swissprot - A0A0H2UKE0
swissprot - F1R701
swissprot - Q5RJA1
ZFIN ID - ZDB-GENE-041014-299
Ensembl - ENSDARG00000041702
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RFX6ENSGALG00000014918Gallus gallus
 RFX6ENSG00000185002Homo sapiens
 Rfx6ENSMUSG00000019900Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rfx4 / A2BGA0 / regulatory factor X, 4 / Q7TNK1* / Q33E94* / Transcription factor RFX4 *ENSDARG0000002639528
rfx3 / regulatory factor X, 3 (influences HLA class II expression) / P48380* / regulatory factor X3*ENSDARG0000001455021
rfx1a / regulatory factor X, 1a (influences HLA class II expression) / RFX1* / P22670* / P48377* / regulatory factor X1* / MHC class II regulatory factor RFX1 *ENSDARG0000000588320
rfx2 / Q5EAP5 / regulatory factor X, 2 (influences HLA class II expression) / P48379* / P48378* / regulatory factor X2* / DNA-binding protein RFX2 *ENSDARG0000001357520
rfx1b / regulatory factor X, 1b (influences HLA class II expression) / RFX1* / P22670* / P48377* / regulatory factor X1* / MHC class II regulatory factor RFX1 *ENSDARG0000007590420
rfx7a / regulatory factor X7a / RFX7* / Q2KHR2* / regulatory factor X7*ENSDARG0000007723712
rfx7b / regulatory factor X7b / RFX7* / Q2KHR2* / regulatory factor X7*ENSDARG0000010369112
rfx5 / regulatory factor X, 5 / P48382* / Q9JL61* / Mus musculus regulatory factor X, 5 (influences HLA class II expression) (Rfx5), transcript variant 2, mRNA.*ENSDARG000000632587


Protein motifs (from Interpro)
Interpro ID Name
 IPR003150  DNA-binding RFX-type winged-helix domain
 IPR011991  ArsR-like helix-turn-helix domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003309 type B pancreatic cell differentiation ISS
 biological_processGO:0003310 pancreatic A cell differentiation ISS
 biological_processGO:0003311 pancreatic D cell differentiation ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0050796 regulation of insulin secretion ISS
 biological_processGO:0090104 pancreatic epsilon cell differentiation ISS
 cellular_componentGO:0005634 nucleus ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001260 endocrine pancreas endocrine pancreas endocrine cell undifferentiated , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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