ENSG00000100450


Homo sapiens

Features
Gene ID: ENSG00000100450
  
Biological name :GZMH
  
Synonyms : granzyme H / GZMH / P20718
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q12
Gene start: 24606480
Gene end: 24609699
  
Corresponding Affymetrix probe sets: 210321_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450576
Ensembl peptide - ENSP00000216338
Ensembl peptide - ENSP00000371988
NCBI entrez gene - 2999     See in Manteia.
OMIM - 116831
RefSeq - XM_011536683
RefSeq - NM_001270780
RefSeq - NM_001270781
RefSeq - NM_033423
RefSeq Peptide - NP_001257709
RefSeq Peptide - NP_001257710
RefSeq Peptide - NP_219491
swissprot - P20718
swissprot - A0A0C4DGJ9
Ensembl - ENSG00000100450
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gzm3ENSDARG00000078451Danio rerio
 gzm3.2ENSDARG00000055986Danio rerio
 gzm3.3ENSDARG00000093990Danio rerio
 gzm3.4ENSDARG00000076814Danio rerio
 ENSGALG00000044661Gallus gallus
 GzmdENSMUSG00000059256Mus musculus
 GzmeENSMUSG00000022156Mus musculus
 GzmfENSMUSG00000015441Mus musculus
 GzmgENSMUSG00000040284Mus musculus
 GzmnENSMUSG00000015443Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GZMB / P10144 / granzyme BENSG0000010045372
CTSG / P08311 / cathepsin GENSG0000010044857
CMA1 / P23946 / chymase 1ENSG0000009200948
GZMA / P12544 / granzyme AENSG0000014564939
PRSS57 / Q6UWY2 / serine protease 57ENSG0000018519839
GZMK / P49863 / granzyme KENSG0000011308837
GZMM / P51124 / granzyme MENSG0000019754037
CFD / P00746 / complement factor DENSG0000019776637


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0019835 cytolysis IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030141 secretory granule IBA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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