Manteia

ENSGALG00000001080

Gallus gallus

Features

Gene ID:	ENSGALG00000001080

Biological name :	NR5A1

Synonyms :	NR5A1 / steroidogenic factor 1

Possible biological names infered from orthology :	nuclear receptor subfamily 5 group A member 1 / P33242 / Q13285

Species:	Gallus gallus

Chr. number:	17
Strand:	-1
Band:
Gene start:	9914203
Gene end:	9930043

Corresponding Affymetrix probe sets:	Gga.571.1.S1_at (Chicken Array)

Cross references:	Ensembl peptide - ENSGALP00000001614 NCBI entrez gene - 395960 See in Manteia. RefSeq - XM_015279334 RefSeq - NM_205077 RefSeq - XM_015279332 RefSeq - XM_015279333 RefSeq Peptide - NP_990408 swissprot - E1BXV1 Ensembl - ENSGALG00000001080

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nr5a1a	ENSDARG00000103176	Danio rerio
nr5a1b	ENSDARG00000023362	Danio rerio
nr6a1a	ENSDARG00000096224	Danio rerio
NR5A1	ENSG00000136931	Homo sapiens
Nr5a1	ENSMUSG00000026751	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
NR5A2 / nuclear receptor subfamily 5 group A member 2 / O00482* / P45448*	ENSGALG00000002182	71
NR1D2 / nuclear receptor subfamily 1 group D member 2 / Q14995* / Q60674*	ENSGALG00000011291	23
	ENSGALG00000001035	20
NR6A1 / nuclear receptor subfamily 6 group A member 1 / Q15406* / Q64249*	ENSGALG00000001073	20
RORB / RAR related orphan receptor B / Q8R1B8* / Q92753* / Nuclear receptor ROR-beta *	ENSGALG00000015150	20
RORA / nuclear receptor ROR-alpha / P51448* / P35398* / RAR related orphan receptor A* / RAR-related orphan receptor alpha*	ENSGALG00000003759	19
PPARD / peroxisome proliferator-activated receptor delta / P35396* / Q03181*	ENSGALG00000002588	18
PPARG / peroxisome proliferator activated receptor gamma / P37231*	ENSGALG00000004974	18
RORC / RAR related orphan receptor C / P51449* / P51450* / Nuclear receptor ROR-gamma *	ENSGALG00000033941	18
PPARA / peroxisome proliferator-activated receptor alpha / P23204* / Q07869*	ENSGALG00000041470	17

Protein motifs (from Interpro)

Interpro ID	Name
IPR000536	Nuclear hormone receptor, ligand-binding domain
IPR001628	Zinc finger, nuclear hormone receptor-type
IPR001723	Nuclear hormone receptor
IPR013088	Zinc finger, NHR/GATA-type
IPR016355	Nuclear hormone receptor family 5

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001553	luteinization	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0007530	sex determination	IEA
biological_process	GO:0008584	male gonad development	IEA
biological_process	GO:0008585	female gonad development	IEA
biological_process	GO:0009755	hormone-mediated signaling pathway	IBA
biological_process	GO:0009888	tissue development	IEA
biological_process	GO:0010259	multicellular organism aging	IEA
biological_process	GO:0010628	positive regulation of gene expression	IEA
biological_process	GO:0022414	reproductive process	IEA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030325	adrenal gland development	IEA
biological_process	GO:0030522	intracellular receptor signaling pathway	IEA
biological_process	GO:0042445	hormone metabolic process	IEA
biological_process	GO:0043401	steroid hormone mediated signaling pathway	IEA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0051457	maintenance of protein location in nucleus	IEA
biological_process	GO:2000020	positive regulation of male gonad development	IEA
biological_process	GO:2000195	negative regulation of female gonad development	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0090575	RNA polymerase II transcription factor complex	IEA
molecular_function	GO:0000976	transcription regulatory region sequence-specific DNA binding	IBA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IEA
molecular_function	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003682	chromatin binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	IEA
molecular_function	GO:0003707	steroid hormone receptor activity	IEA
molecular_function	GO:0004879	nuclear receptor activity	IEA
molecular_function	GO:0005543	phospholipid binding	IEA
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0019899	enzyme binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Nuclear Receptor transcription pathway

SUMOylation of intracellular receptors

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSGALG00000007971	SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*	/ reaction
ENSGALG00000008435	SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*	/ complex / reaction
ENSGALG00000006428	UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr