ENSGALG00000041470


Gallus gallus

Features
Gene ID: ENSGALG00000041470
  
Biological name :PPARA
  
Synonyms : peroxisome proliferator-activated receptor alpha / PPARA
  
Possible biological names infered from orthology : P23204 / Q07869
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 71331992
Gene end: 71363344
  
Corresponding Affymetrix probe sets: Gga.4006.1.S1_at (Chicken Array)   Gga.4006.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053048
NCBI entrez gene - 374120     See in Manteia.
RefSeq - XM_015289959
RefSeq - NM_001001464
RefSeq - XM_015289947
RefSeq - XM_015289951
RefSeq - XM_015289929
RefSeq - XM_015289937
RefSeq - XM_015289940
RefSeq - XM_015289942
RefSeq Peptide - NP_001001464
swissprot - A0A1D5PJQ2
Ensembl - ENSGALG00000041470
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pparaaENSDARG00000031777Danio rerio
 pparabENSDARG00000054323Danio rerio
 PPARAENSG00000186951Homo sapiens
 PparaENSMUSG00000022383Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPARD / peroxisome proliferator-activated receptor delta / P35396* / Q03181*ENSGALG0000000258862
PPARG / peroxisome proliferator activated receptor gamma / P37231*ENSGALG0000000497456
NR1D2 / nuclear receptor subfamily 1 group D member 2 / Q14995* / Q60674*ENSGALG0000001129129
RORA / nuclear receptor ROR-alpha / P51448* / P35398* / RAR related orphan receptor A* / RAR-related orphan receptor alpha*ENSGALG0000000375924
RORB / RAR related orphan receptor B / Q8R1B8* / Q92753* / Nuclear receptor ROR-beta *ENSGALG0000001515023
RORC / RAR related orphan receptor C / P51449* / P51450* / Nuclear receptor ROR-gamma *ENSGALG0000003394123
ENSGALG0000000103522
NR5A2 / nuclear receptor subfamily 5 group A member 2 / O00482* / P45448*ENSGALG0000000218219
NR6A1 / nuclear receptor subfamily 6 group A member 1 / Q15406* / Q64249*ENSGALG0000000107318
NR5A1 / steroidogenic factor 1 / P33242* / Q13285* / nuclear receptor subfamily 5 group A member 1*ENSGALG0000000108017


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003074  Peroxisome proliferator-activated receptor
 IPR003076  Peroxisome proliferator-activated receptor alpha
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IEA
 biological_processGO:0010871 negative regulation of receptor biosynthetic process IEA
 biological_processGO:0010887 negative regulation of cholesterol storage IEA
 biological_processGO:0010891 negative regulation of sequestering of triglyceride IEA
 biological_processGO:0019217 regulation of fatty acid metabolic process IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0032099 negative regulation of appetite IEA
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045722 positive regulation of gluconeogenesis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046321 positive regulation of fatty acid oxidation IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0070166 enamel mineralization IEA
 biological_processGO:0072363 regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter IEA
 biological_processGO:0072366 regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter IEA
 biological_processGO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1903038 negative regulation of leukocyte cell-cell adhesion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000015937 FABP1 / fatty acid binding protein 1 / P07148* / P12710* / Fatty acid-binding protein, liver *  / reaction
 ENSGALG00000040006 TBL1X / TBL1Y* / Q9QXE7* / O60907* / Q9BQ87* / transducin beta like 1 X-linked* / transducin beta like 1 Y-linked* / F-box-like/WD repeat-containing protein TBL1X *  / complex / reaction
 ENSGALG00000039182 TBL1XR1 / F-box-like/WD repeat-containing protein TBL1XR1 / Q8BHJ5* / Q9BZK7* / transducin beta like 1 X-linked receptor 1*  / complex / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr