ENSMUSG00000022032


Mus musculus

Features
Gene ID: ENSMUSG00000022032
  
Biological name :Scara5
  
Synonyms : Q8K299 / Scara5 / Scavenger receptor class A member 5
  
Possible biological names infered from orthology : Q6ZMJ2
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D1
Gene start: 65666403
Gene end: 65764826
  
Corresponding Affymetrix probe sets: 10416023 (MoGene1.0st)   1431336_at (Mouse Genome 430 2.0 Array)   1451204_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022610
Ensembl peptide - ENSMUSP00000063391
NCBI entrez gene - 71145     See in Manteia.
MGI - MGI:1918395
RefSeq - NM_001168318
RefSeq - NM_028903
RefSeq Peptide - NP_001161790
RefSeq Peptide - NP_083179
swissprot - Q8K299
Ensembl - ENSMUSG00000022032
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5RFW0ENSDARG00000010425Danio rerio
 SCARA5ENSGALG00000016580Gallus gallus
 Q6ZMJ2ENSG00000168079Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Msr1 / P30204 / Macrophage scavenger receptor types I and II / P21757* / macrophage scavenger receptor 1*ENSMUSG0000002504433
Marco / Q60754 / Macrophage receptor MARCO / Q9UEW3* / macrophage receptor with collagenous structure*ENSMUSG0000002639022
Loxl4 / Q924C6 / Lysyl oxidase homolog 4 / Q96JB6* / lysyl oxidase like 4*ENSMUSG0000002518515
Loxl2 / P58022 / Lysyl oxidase homolog 2 / Q9Y4K0* / lysyl oxidase like 2*ENSMUSG0000003420515
Loxl3 / Q9Z175 / Lysyl oxidase homolog 3 / P58215* / lysyl oxidase like 3*ENSMUSG0000000069314
Cd6 / Q61003 / T-cell differentiation antigen CD6 / P30203* / CD6 molecule*ENSMUSG0000002467012
Loxl1 / lysyl oxidase like 1 / Q08397*ENSMUSG000000323346
Lox / P28301 / Protein-lysine 6-oxidase / P28300* / lysyl oxidase*ENSMUSG000000245292


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR008160  Collagen triple helix repeat
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR017448  SRCR-like domain
 IPR034726  Scavenger receptor class A member 5
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006879 cellular iron ion homeostasis IDA
 biological_processGO:0006897 endocytosis IDA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0034605 cellular response to heat IDA
 biological_processGO:0034755 iron ion transmembrane transport IDA
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0070207 protein homotrimerization IPI
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0070287 ferritin receptor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0009646 urinary bladder inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0020386 adipose tissue inflammation "local accumulation of fluid, plasma proteins, and leukocytes in adipose tissue" [MGI:anna, PMID:24662293, PMID:24695736, PMID:26629401]
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Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024661 Fth1 / P09528 / Ferritin heavy chain Ferritin heavy chain, N-terminally processed / P02794* / ferritin heavy chain 1*  / complex / reaction
 ENSMUSG00000022032 Q8K299 / Scara5 / Scavenger receptor class A member 5 / Q6ZMJ2*  / complex






 

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