ENSMUSG00000026390


Mus musculus

Features
Gene ID: ENSMUSG00000026390
  
Biological name :Marco
  
Synonyms : Macrophage receptor MARCO / Marco / Q60754
  
Possible biological names infered from orthology : macrophage receptor with collagenous structure / Q9UEW3
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.3
Gene start: 120474538
Gene end: 120505024
  
Corresponding Affymetrix probe sets: 10357261 (MoGene1.0st)   1449498_at (Mouse Genome 430 2.0 Array)   1458297_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027639
Ensembl peptide - ENSMUSP00000140948
NCBI entrez gene - 17167     See in Manteia.
MGI - MGI:1309998
RefSeq - NM_010766
RefSeq Peptide - NP_034896
swissprot - A2RT24
swissprot - A0A087WS94
swissprot - Q60754
Ensembl - ENSMUSG00000026390
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 marcoENSDARG00000059294Danio rerio
 MARCOENSGALG00000012119Gallus gallus
 MARCOENSG00000019169Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K299 / Scara5 / Scavenger receptor class A member 5 / Q6ZMJ2*ENSMUSG0000002203221
Msr1 / P30204 / Macrophage scavenger receptor types I and II / P21757* / macrophage scavenger receptor 1*ENSMUSG0000002504421
Loxl2 / P58022 / Lysyl oxidase homolog 2 / Q9Y4K0* / lysyl oxidase like 2*ENSMUSG0000003420517
Loxl3 / Q9Z175 / Lysyl oxidase homolog 3 / P58215* / lysyl oxidase like 3*ENSMUSG0000000069314
Loxl4 / Q924C6 / Lysyl oxidase homolog 4 / Q96JB6* / lysyl oxidase like 4*ENSMUSG0000002518514
Cd6 / Q61003 / T-cell differentiation antigen CD6 / P30203* / CD6 molecule*ENSMUSG0000002467013
Loxl1 / lysyl oxidase like 1 / Q08397*ENSMUSG000000323346
Lox / P28301 / Protein-lysine 6-oxidase / P28300* / lysyl oxidase*ENSMUSG000000245292


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR008160  Collagen triple helix repeat
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR017448  SRCR-like domain
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006897 endocytosis IMP
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0043277 apoptotic cell clearance IMP
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA


Pathways (from Reactome)
Pathway description
Scavenging by Class A Receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map3k7tm1.1Mds/Map3k7tm1.1Mds
Genetic Background: Not Specified

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map3k7tm1.1Mds/Map3k7tm1.1Mds
Genetic Background: Not Specified

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Map3k7tm1.1Mds/Map3k7tm1.1Mds
Genetic Background: Not Specified

Allelic Composition: Marcotm1Ktry/Marcotm1Ktry,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: B6.129-Marcotm1Ktry Msr1tm1Csk

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map3k7tm1.1Mds/Map3k7tm1.1Mds
Genetic Background: Not Specified

Allelic Composition: Marcotm1Ktry/Marcotm1Ktry,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: B6.129-Marcotm1Ktry Msr1tm1Csk

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map3k7tm1.1Mds/Map3k7tm1.1Mds
Genetic Background: Not Specified

Allelic Composition: Marcotm1Ktry/Marcotm1Ktry,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: B6.129-Marcotm1Ktry Msr1tm1Csk

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Marcotm1Ktry/Marcotm1Ktry,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: B6.129-Marcotm1Ktry Msr1tm1Csk

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map3k7tm1.1Mds/Map3k7tm1.1Mds
Genetic Background: Not Specified

 MP:0010740 abnormal dendritic cell chemotaxis "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
Show

Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026390 Marco / Q60754 / Macrophage receptor MARCO / Q9UEW3* / macrophage receptor with collagenous structure*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr