ENSMUSG00000034205


Mus musculus

Features
Gene ID: ENSMUSG00000034205
  
Biological name :Loxl2
  
Synonyms : Loxl2 / Lysyl oxidase homolog 2 / P58022
  
Possible biological names infered from orthology : lysyl oxidase like 2 / Q9Y4K0
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D2
Gene start: 69609068
Gene end: 69695834
  
Corresponding Affymetrix probe sets: 10416215 (MoGene1.0st)   1431004_at (Mouse Genome 430 2.0 Array)   1452436_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022660
Ensembl peptide - ENSMUSP00000097987
NCBI entrez gene - 94352     See in Manteia.
MGI - MGI:2137913
RefSeq - XM_006519747
RefSeq - NM_033325
RefSeq - XM_006519745
RefSeq - XM_006519746
RefSeq - XM_006519744
RefSeq Peptide - NP_201582
swissprot - P58022
Ensembl - ENSMUSG00000034205
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A1L1V4ENSDARG00000044074Danio rerio
 F1QQC3ENSDARG00000044010Danio rerio
 ENSGALG00000038458Gallus gallus
 LOXL2ENSG00000134013Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Loxl3 / Q9Z175 / Lysyl oxidase homolog 3 / P58215* / lysyl oxidase like 3*ENSMUSG0000000069353
Loxl4 / Q924C6 / Lysyl oxidase homolog 4 / Q96JB6* / lysyl oxidase like 4*ENSMUSG0000002518553
Loxl1 / lysyl oxidase like 1 / Q08397*ENSMUSG0000003233420
Cd6 / Q61003 / T-cell differentiation antigen CD6 / P30203* / CD6 molecule*ENSMUSG0000002467018
Lox / P28301 / Protein-lysine 6-oxidase / P28300* / lysyl oxidase*ENSMUSG0000002452916
Marco / Q60754 / Macrophage receptor MARCO / Q9UEW3* / macrophage receptor with collagenous structure*ENSMUSG0000002639011
Q8K299 / Scara5 / Scavenger receptor class A member 5 / Q6ZMJ2*ENSMUSG0000002203210
Msr1 / P30204 / Macrophage scavenger receptor types I and II / P21757* / macrophage scavenger receptor 1*ENSMUSG0000002504410


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001695  Lysyl oxidase
 IPR017448  SRCR-like domain
 IPR019828  Lysyl oxidase, conserved site
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0001837 epithelial to mesenchymal transition ISO
 biological_processGO:0001935 endothelial cell proliferation ISO
 biological_processGO:0002040 sprouting angiogenesis ISO
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006464 cellular protein modification process ISS
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISO
 biological_processGO:0018057 peptidyl-lysine oxidation ISO
 biological_processGO:0030199 collagen fibril organization ISS
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IMP
 biological_processGO:0043542 endothelial cell migration ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0046688 response to copper ion ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070828 heterochromatin organization ISO
 biological_processGO:1902455 negative regulation of stem cell population maintenance IDA
 cellular_componentGO:0000785 chromatin ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane ISS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0004720 protein-lysine 6-oxidase activity ISO
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070492 oligosaccharide binding ISS


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0009820 abnormal liver vasculature morphology "any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0011112 partial lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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