ENSDARG00000044010


Danio rerio
regulationloxl2atranscriptionactivitycellorganizationdna-templateddomainlysyloxidaseepithelialmesenchymaltransitionendothelialchromatincollagenmembraneionbindingoxidoreductasevesselsrcrimmunoglobulin-likefoldsrcr-likeconservedsiternapolymeraseiiresponse

Features
Gene ID: ENSDARG00000044010
  
Biological name :loxl2a
  
Synonyms : F1QQC3 / loxl2a / lysyl oxidase-like 2a
  
Possible biological names infered from orthology : LOXL2 / Lysyl oxidase homolog 2 / lysyl oxidase like 2 / P58022 / Q9Y4K0
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 20407888
Gene end: 20445549
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000064612
NCBI entrez gene - 565508     See in Manteia.
RefSeq - NM_001099244
RefSeq Peptide - NP_001092714
swissprot - F1QQC3
swissprot - A0A0H2UKE3
ZFIN ID - ZDB-GENE-070818-1
Ensembl - ENSDARG00000044010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000038458Gallus gallus
 LOXL2ENSG00000134013Homo sapiens
 Loxl2ENSMUSG00000034205Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
loxl2b / A1L1V4 / lysyl oxidase-like 2b / LOXL2* / Q9Y4K0* / P58022* / lysyl oxidase like 2* / Lysyl oxidase homolog 2 *ENSDARG0000004407473
B8A4W9 / loxl3b / lysyl oxidase-like 3bENSDARG0000003956358
F1RD85 / loxl3a / lysyl oxidase-like 3aENSDARG0000007630657
loxl4 / lysyl oxidase-like 4ENSDARG0000002508953
si:cabz01100188.1ENSDARG0000010544227
loxl1 / lysyl oxidase-like 1 / Q08397*ENSDARG0000005445120
loxa / lysyl oxidase aENSDARG0000000325919
loxl5b / lysyl oxidase-like 5bENSDARG0000007690419
loxl5a / lysyl oxidase-like 5aENSDARG0000007168018
si:dkey-21h14.3ENSDARG0000009604712
si:dkey-242e21.3 / CD6* / P30203* / Q61003* / CD6 molecule* / T-cell differentiation antigen CD6 *ENSDARG0000007572311
si:ch211-150o23.3ENSDARG0000007850211
scara5 / Q5RFW0 / scavenger receptor class A, member 5 (putative) / Q8K299* / Q6ZMJ2* / scavenger receptor class A member 5*ENSDARG0000001042510
marco / macrophage receptor with collagenous structure / Q9UEW3*ENSDARG000000592949
CT583642.2ENSDARG000001113156


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001695  Lysyl oxidase
 IPR013783  Immunoglobulin-like fold
 IPR017448  SRCR-like domain
 IPR019828  Lysyl oxidase, conserved site


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressresponse to abiotic stimulusanatomical structure developmentcellular developmental processepithelial cell proliferationcellular component organizationestablishment of localizationoxidation-reduction processlocalization of cellmovement of cell or subcellular componenttissue migrationmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressresponse to abiotic stimulusanatomical structure developmentcellular developmental processepithelial cell proliferationcellular component organizationestablishment of localizationoxidation-reduction processlocalization of cellmovement of cell or subcellular componenttissue migrationmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressresponse to abiotic stimulusanatomical structure developmentcellular developmental processepithelial cell proliferationcellular component organizationestablishment of localizationoxidation-reduction processlocalization of cellmovement of cell or subcellular componenttissue migrationmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressresponse to abiotic stimulusanatomical structure developmentcellular developmental processepithelial cell proliferationcellular component organizationestablishment of localizationoxidation-reduction processlocalization of cellmovement of cell or subcellular componenttissue migrationmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressresponse to abiotic stimulusanatomical structure developmentcellular developmental processepithelial cell proliferationcellular component organizationestablishment of localizationoxidation-reduction processlocalization of cellmovement of cell or subcellular componenttissue migrationmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressresponse to abiotic stimulusanatomical structure developmentcellular developmental processepithelial cell proliferationcellular component organizationestablishment of localizationoxidation-reduction processlocalization of cellmovement of cell or subcellular componenttissue migrationmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressresponse to abiotic stimulusanatomical structure developmentcellular developmental processepithelial cell proliferationcellular component organizationestablishment of localizationoxidation-reduction processlocalization of cellmovement of cell or subcellular componenttissue migrationmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressresponse to abiotic stimulusanatomical structure developmentcellular developmental processepithelial cell proliferationcellular component organizationestablishment of localizationoxidation-reduction processlocalization of cellmovement of cell or subcellular componenttissue migrationmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressresponse to abiotic stimulusanatomical structure developmentcellular developmental processepithelial cell proliferationcellular component organizationestablishment of localizationoxidation-reduction processlocalization of cellmovement of cell or subcellular componenttissue migrationmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressresponse to abiotic stimulusanatomical structure developmentcellular developmental processepithelial cell proliferationcellular component organizationestablishment of localizationoxidation-reduction processlocalization of cellmovement of cell or subcellular componenttissue migrationmaintenance of cell numbernitrogennitrogen compound metabolic processbiosynthbiosynthetic processcellularcellular metabolic processprimary primary metabolic processorganic organic substance metabolic processresponseresponse to stressresponseresponse to abiotic stimulusanatomicanatomical structure developmentcellularcellular developmental processepitheliepithelial cell proliferationcellularcellular component organizationestablisestablishment of localizationoxidatiooxidation-reduction processlocalizalocalization of cellmovementmovement of cell or subcellular componenttissue mtissue migrationmaintenamaintenance of cell number
oxidoreductase activitycatalytic activity, acting on a proteinscavenger receptor activityion bindingoxidoreductase activitycatalytic activity, acting on a proteinscavenger receptor activityion bindingoxidoreductase activitycatalytic activity, acting on a proteinscavenger receptor activityion bindingoxidoreductase activitycatalytic activity, acting on a proteinscavenger receptor activityion bindingoxidoreductase activitycatalytic activity, acting on a proteinscavenger receptor activityion bindingoxidoreductase activitycatalytic activity, acting on a proteinscavenger receptor activityion bindingoxidoreductase activitycatalytic activity, acting on a proteinscavenger receptor activityion bindingoxidoreductase activitycatalytic activity, acting on a proteinscavenger receptor activityion bindingoxidoreductase activitycatalytic activity, acting on a proteinscavenger receptor activityion bindingoxidoreductase activitycatalytic activity, acting on a proteinscavenger receptor activityion bindingoxidoreductase activityoxidoreductase activitycatalytic activity, acting on a procatalytic activity, acting on a proteinscavenger receptor activityscavenger receptor activityion bindingion binding
cellorganelleextracellular regionmembranecellorganelleextracellular regionmembranecellorganelleextracellular regionmembranecellorganelleextracellular regionmembranecellorganelleextracellular regionmembranecellorganelleextracellular regionmembranecellorganelleextracellular regionmembranecellorganelleextracellular regionmembranecellorganelleextracellular regionmembranecellorganelleextracellular regionmembranecellcellorganelleorganelleextracellular regionextracellular regionmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001666 response to hypoxia ISS
 biological_processGO:0001837 epithelial to mesenchymal transition ISS
 biological_processGO:0001935 endothelial cell proliferation ISS
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISS
 biological_processGO:0018057 peptidyl-lysine oxidation ISS
 biological_processGO:0030199 collagen fibril organization ISS
 biological_processGO:0032332 positive regulation of chondrocyte differentiation ISS
 biological_processGO:0043542 endothelial cell migration ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070828 heterochromatin organization ISS
 biological_processGO:1902455 negative regulation of stem cell population maintenance ISS
 cellular_componentGO:0000785 chromatin ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004720 protein-lysine 6-oxidase activity ISS
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain anterior region increased curvature , abnormal
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 ZFA:0000012 central nervous system central nervous system increased distribution , abnormal
central nervous system decreased distribution , abnormal
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 ZFA:0000029 hindbrain hindbrain increased distribution , abnormal
hindbrain decreased distribution , abnormal
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 ZFA:0000075 spinal cord spinal cord increased distribution , abnormal
spinal cord decreased distribution , abnormal
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 ZFA:0000107 eye eye increased distribution , abnormal
eye decreased distribution , abnormal
eye flattened , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel arrested , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel disorganized , abnormal
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 ZFA:0005604 angiogenic sprout angiogenic sprout decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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