ENSMUSG00000024670


Mus musculus

Features
Gene ID: ENSMUSG00000024670
  
Biological name :Cd6
  
Synonyms : Cd6 / Q61003 / T-cell differentiation antigen CD6
  
Possible biological names infered from orthology : CD6 molecule / P30203
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 10789341
Gene end: 10830058
  
Corresponding Affymetrix probe sets: 10466054 (MoGene1.0st)   1451910_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046861
Ensembl peptide - ENSMUSP00000079172
Ensembl peptide - ENSMUSP00000134639
NCBI entrez gene - 12511     See in Manteia.
MGI - MGI:103566
RefSeq - XM_006526622
RefSeq - NM_001037801
RefSeq - NM_009852
RefSeq Peptide - NP_001032890
RefSeq Peptide - NP_033982
swissprot - Q61003
swissprot - G3UZU7
Ensembl - ENSMUSG00000024670
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-242e21.3ENSDARG00000075723Danio rerio
 CD6ENSGALG00000043016Gallus gallus
 CD6ENSG00000013725Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Loxl4 / Q924C6 / Lysyl oxidase homolog 4 / Q96JB6* / lysyl oxidase like 4*ENSMUSG0000002518521
Loxl2 / P58022 / Lysyl oxidase homolog 2 / Q9Y4K0* / lysyl oxidase like 2*ENSMUSG0000003420521
Loxl3 / Q9Z175 / Lysyl oxidase homolog 3 / P58215* / lysyl oxidase like 3*ENSMUSG0000000069320
Marco / Q60754 / Macrophage receptor MARCO / Q9UEW3* / macrophage receptor with collagenous structure*ENSMUSG0000002639010
Q8K299 / Scara5 / Scavenger receptor class A member 5 / Q6ZMJ2*ENSMUSG000000220329
Msr1 / P30204 / Macrophage scavenger receptor types I and II / P21757* / macrophage scavenger receptor 1*ENSMUSG000000250449
Loxl1 / lysyl oxidase like 1 / Q08397*ENSMUSG000000323348
Lox / P28301 / Protein-lysine 6-oxidase / P28300* / lysyl oxidase*ENSMUSG000000245296


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR017448  SRCR-like domain
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001771 immunological synapse formation ISS
 biological_processGO:0002438 acute inflammatory response to antigenic stimulus ISS
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway ISO
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0042102 positive regulation of T cell proliferation ISS
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response ISS
 cellular_componentGO:0001772 immunological synapse ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane ISO
 cellular_componentGO:0042101 T cell receptor complex ISS
 molecular_functionGO:0001530 lipopolysaccharide binding ISS
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0070891 lipoteichoic acid binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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