ENSMUSG00000025044


Mus musculus

Features
Gene ID: ENSMUSG00000025044
  
Biological name :Msr1
  
Synonyms : Macrophage scavenger receptor types I and II / Msr1 / P30204
  
Possible biological names infered from orthology : macrophage scavenger receptor 1 / P21757
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A4
Gene start: 39581685
Gene end: 39642673
  
Corresponding Affymetrix probe sets: 10578264 (MoGene1.0st)   1422062_at (Mouse Genome 430 2.0 Array)   1425434_a_at (Mouse Genome 430 2.0 Array)   1425435_at (Mouse Genome 430 2.0 Array)   1448061_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026021
Ensembl peptide - ENSMUSP00000132535
Ensembl peptide - ENSMUSP00000147644
NCBI entrez gene - 20288     See in Manteia.
MGI - MGI:98257
RefSeq - XM_006509312
RefSeq - NM_001113326
RefSeq - NM_031195
RefSeq - XM_006509311
RefSeq Peptide - NP_112472
RefSeq Peptide - NP_001106797
swissprot - P30204
swissprot - Q8CED7
swissprot - A0A1B0GRS5
Ensembl - ENSMUSG00000025044
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MSR1ENSG00000038945Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K299 / Scara5 / Scavenger receptor class A member 5 / Q6ZMJ2*ENSMUSG0000002203236
Marco / Q60754 / Macrophage receptor MARCO / Q9UEW3* / macrophage receptor with collagenous structure*ENSMUSG0000002639024
Loxl2 / P58022 / Lysyl oxidase homolog 2 / Q9Y4K0* / lysyl oxidase like 2*ENSMUSG0000003420518
Loxl3 / Q9Z175 / Lysyl oxidase homolog 3 / P58215* / lysyl oxidase like 3*ENSMUSG0000000069316
Loxl4 / Q924C6 / Lysyl oxidase homolog 4 / Q96JB6* / lysyl oxidase like 4*ENSMUSG0000002518516
Cd6 / Q61003 / T-cell differentiation antigen CD6 / P30203* / CD6 molecule*ENSMUSG0000002467013
Loxl1 / lysyl oxidase like 1 / Q08397*ENSMUSG000000323345
Lox / P28301 / Protein-lysine 6-oxidase / P28300* / lysyl oxidase*ENSMUSG000000245293


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR003543  Macrophage scavenger receptor
 IPR008160  Collagen triple helix repeat
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR017448  SRCR-like domain
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006911 phagocytosis, engulfment IGI
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IGI
 biological_processGO:0010886 positive regulation of cholesterol storage IMP
 biological_processGO:0030301 cholesterol transport IMP
 biological_processGO:0034381 plasma lipoprotein particle clearance IMP
 biological_processGO:0042953 lipoprotein transport IMP
 biological_processGO:0097242 amyloid-beta clearance IMP
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034362 low-density lipoprotein particle IEA
 molecular_functionGO:0001540 amyloid-beta binding IGI
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0030169 low-density lipoprotein particle binding IMP


Pathways (from Reactome)
Pathway description
Scavenging by Class A Receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Marcotm1Ktry/Marcotm1Ktry,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: B6.129-Marcotm1Ktry Msr1tm1Csk

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Marcotm1Ktry/Marcotm1Ktry,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: B6.129-Marcotm1Ktry Msr1tm1Csk

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prnptm2Tuzi/Prnptm2Edin
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Marcotm1Ktry/Marcotm1Ktry,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: B6.129-Marcotm1Ktry Msr1tm1Csk

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Marcotm1Ktry/Marcotm1Ktry,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: B6.129-Marcotm1Ktry Msr1tm1Csk

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Hcfc2em1Btlr/Hcfc2em1Btlr
Genetic Background: C57BL/6J-Hcfc2em1Btlr

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025044 Msr1 / P30204 / Macrophage scavenger receptor types I and II / P21757* / macrophage scavenger receptor 1*  / complex
 ENSMUSG00000031503 Col4a2 / P08122 / Collagen alpha-2(IV) chain Canstatin / P08572* / collagen type IV alpha 2 chain*  / complex / reaction
 ENSMUSG00000031502 Col4a1 / P02463 / Collagen alpha-1(IV) chain Arresten / P02462* / collagen type IV alpha 1 chain*  / complex / reaction






 

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