ENSMUSG00000043614


Mus musculus

Features
Gene ID: ENSMUSG00000043614
  
Biological name :Vps37d
  
Synonyms : Q810I0 / vacuolar protein sorting 37D / Vps37d
  
Possible biological names infered from orthology : Q86XT2 / VPS37D, ESCRT-I subunit
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 135072900
Gene end: 135078266
  
Corresponding Affymetrix probe sets: 10534420 (MoGene1.0st)   1457736_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063762
Ensembl peptide - ENSMUSP00000075559
NCBI entrez gene - 194309     See in Manteia.
MGI - MGI:2159402
RefSeq - XM_011240873
RefSeq - NM_001199677
RefSeq - NM_177574
RefSeq Peptide - NP_808242
RefSeq Peptide - NP_001186606
swissprot - Q810I0
Ensembl - ENSMUSG00000043614
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-284f22.3ENSDARG00000097055Danio rerio
 Q86XT2ENSG00000176428Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R0J7 / Vps37b / vacuolar protein sorting 37B / Q9H9H4* / VPS37B, ESCRT-I subunit*ENSMUSG0000006627831
Q8R105 / Vps37c / vacuolar protein sorting 37C / A5D8V6* / VPS37C, ESCRT-I subunit*ENSMUSG0000004883230
Q8CHS8 / Vps37a / vacuolar protein sorting 37A / Q8NEZ2* / VPS37A, ESCRT-I subunit*ENSMUSG0000003160016


Protein motifs (from Interpro)
Interpro ID Name
 IPR009851  Modifier of rudimentary, Modr


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032509 endosome transport via multivesicular body sorting pathway IEA
 cellular_componentGO:0000813 ESCRT I complex ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0003385 abnormal body wall "malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014402 Q61187 / Tsg101 / tumor susceptibility gene 101 / Q99816* / tumor susceptibility 101*  / complex
 ENSMUSG00000031813 Mvb12a / Q78HU3 / Multivesicular body subunit 12A / Q96EY5*  / complex
 ENSMUSG00000038740 Mvb12b / Q6KAU4 / Multivesicular body subunit 12B / Q9H7P6*  / complex
 ENSMUSG00000006058 Snf8 / Q9CZ28 / Mus musculus SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) (Snf8), transcript variant 2, mRNA. / Q96H20* / SNF8, ESCRT-II complex subunit*  / reaction
 ENSMUSG00000078656 Vps25 / Q9CQ80 / vacuolar protein sorting 25 / Q9BRG1* / vacuolar protein sorting 25 homolog*  / reaction
 ENSMUSG00000026718 Stam / P70297 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / Q92783* / signal transducing adaptor molecule*  / reaction
 ENSMUSG00000031479 Vps36 / Q91XD6 / vacuolar protein sorting 36 / Q86VN1* / vacuolar protein sorting 36 homolog*  / reaction
 ENSMUSG00000115987 Vps28 / Q9D1C8 / vacuolar protein sorting 28 / Q9UK41* / VPS28, ESCRT-I subunit*  / complex
 ENSMUSG00000055371 Stam2 / O88811 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / signal transducing adaptor molecule 2*  / reaction
 ENSMUSG00000028437 Ubap1 / Q8BH48 / ubiquitin-associated protein 1 / Q9NZ09*  / complex






 

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