ENSMUSG00000078656


Mus musculus

Features
Gene ID: ENSMUSG00000078656
  
Biological name :Vps25
  
Synonyms : Q9CQ80 / vacuolar protein sorting 25 / Vps25
  
Possible biological names infered from orthology : Q9BRG1 / vacuolar protein sorting 25 homolog
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 101253707
Gene end: 101259549
  
Corresponding Affymetrix probe sets: 10381304 (MoGene1.0st)   1421050_at (Mouse Genome 430 2.0 Array)   1421051_s_at (Mouse Genome 430 2.0 Array)   1428621_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097981
Ensembl peptide - ENSMUSP00000042088
Ensembl peptide - ENSMUSP00000102901
Ensembl peptide - ENSMUSP00000131026
Ensembl peptide - ENSMUSP00000114100
Ensembl peptide - ENSMUSP00000007533
NCBI entrez gene - 28084     See in Manteia.
MGI - MGI:106354
RefSeq - XM_017314585
RefSeq - NM_001284411
RefSeq - NM_001284412
RefSeq - NM_001284414
RefSeq - NM_026776
RefSeq - XM_006533504
RefSeq - XM_006533505
RefSeq Peptide - NP_001271340
RefSeq Peptide - NP_001271343
RefSeq Peptide - NP_081052
RefSeq Peptide - NP_001271341
swissprot - A2A4J8
swissprot - Q9CQ80
swissprot - E9PXS9
swissprot - A8XY17
swissprot - A2A4K0
Ensembl - ENSMUSG00000078656
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps25ENSDARG00000059079Danio rerio
 VPS25ENSGALG00000034262Gallus gallus
 VPS25ENSG00000131475Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008570  ESCRT-II complex, Vps25 subunit
 IPR014041  ESCRT-II complex, Vps25 subunit, N-terminal winged helix
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
 biological_processGO:0071985 multivesicular body sorting pathway IEA
 cellular_componentGO:0000814 ESCRT II complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005198 structural molecule activity IBA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
Show

Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0003857 abnormal hindlimb zeugopod morphology 
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Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0004342 scapular bone foramen "presence of a hole in either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006058 Snf8 / Q9CZ28 / Mus musculus SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) (Snf8), transcript variant 2, mRNA. / Q96H20* / SNF8, ESCRT-II complex subunit*  / complex
 ENSMUSG00000078656 Vps25 / Q9CQ80 / vacuolar protein sorting 25 / Q9BRG1* / vacuolar protein sorting 25 homolog*  / complex
 ENSMUSG00000014402 Q61187 / Tsg101 / tumor susceptibility gene 101 / Q99816* / tumor susceptibility 101*  / reaction
 ENSMUSG00000066278 Q8R0J7 / Vps37b / vacuolar protein sorting 37B / Q9H9H4* / VPS37B, ESCRT-I subunit*  / reaction
 ENSMUSG00000031813 Mvb12a / Q78HU3 / Multivesicular body subunit 12A / Q96EY5*  / reaction
 ENSMUSG00000031479 Vps36 / Q91XD6 / vacuolar protein sorting 36 / Q86VN1* / vacuolar protein sorting 36 homolog*  / complex
 ENSMUSG00000038740 Mvb12b / Q6KAU4 / Multivesicular body subunit 12B / Q9H7P6*  / reaction
 ENSMUSG00000043614 Q810I0 / Vps37d / vacuolar protein sorting 37D / Q86XT2* / VPS37D, ESCRT-I subunit*  / reaction
 ENSMUSG00000028437 Ubap1 / Q8BH48 / ubiquitin-associated protein 1 / Q9NZ09*  / reaction
 ENSMUSG00000048832 Q8R105 / Vps37c / vacuolar protein sorting 37C / A5D8V6* / VPS37C, ESCRT-I subunit*  / reaction
 ENSMUSG00000115987 Vps28 / Q9D1C8 / vacuolar protein sorting 28 / Q9UK41* / VPS28, ESCRT-I subunit*  / reaction
 ENSMUSG00000031600 Q8CHS8 / Vps37a / vacuolar protein sorting 37A / Q8NEZ2* / VPS37A, ESCRT-I subunit*  / reaction






 

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