ENSDARG00000016494


Danio rerio

Features
Gene ID: ENSDARG00000016494
  
Biological name :ddc
  
Synonyms : ddc / dopa decarboxylase
  
Possible biological names infered from orthology : Aromatic-L-amino-acid decarboxylase / O88533 / P20711
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 8298542
Gene end: 8342749
  
Corresponding Affymetrix probe sets: Dr.26319.1.A1_at (Zebrafish Array)   Dr.861.1.S1_at (Zebrafish Array)   NM_213342_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000005382
NCBI entrez gene - 406651     See in Manteia.
RefSeq - NM_213342
RefSeq Peptide - NP_998507
swissprot - Q7SZR0
ZFIN ID - ZDB-GENE-040426-2656
Ensembl - ENSDARG00000016494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DDCENSGALG00000013094Gallus gallus
 DDCENSG00000132437Homo sapiens
 DdcENSMUSG00000020182Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hdc / histidine decarboxylase / P19113* / P23738*ENSDARG0000007545449
gad2 / glutamate decarboxylase 2 / P48320* / Q05329* / glutamic acid decarboxylase 2*ENSDARG0000001553723
zgc:163121ENSDARG0000005537023
gad1b / glutamate decarboxylase 1b / GAD1* / Q99259* / P48318* / glutamate decarboxylase 1*ENSDARG0000002741922
csad / cysteine sulfinic acid decarboxylase / Q9DBE0* / Q9Y600*ENSDARG0000002634821
gad1a / glutamate decarboxylase 1a / GAD1* / Q99259* / P48318* / glutamate decarboxylase 1*ENSDARG0000009341121


Protein motifs (from Interpro)
Interpro ID Name
 IPR002129  Pyridoxal phosphate-dependent decarboxylase
 IPR010977  Aromatic-L-amino-acid decarboxylase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR021115  Pyridoxal-phosphate binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA


Pathways (from Reactome)
Pathway description
Catecholamine biosynthesis
Serotonin and melatonin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased volume , abnormal
brain apoptotic , abnormal
brain has fewer parts of type cell , abnormal
Show

 ZFA:0000101 diencephalon diencephalon dopaminergic neuron spatial pattern , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
Show

 ZFA:0001115 trunk trunk apoptotic , abnormal
Show

 ZFA:0009301 dopaminergic neuron dopaminergic neuron decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000016494 ddc / dopa decarboxylase / O88533* / P20711* / Aromatic-L-amino-acid decarboxylase *  / complex






 

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