ENSMUSG00000020182


Mus musculus

Features
Gene ID: ENSMUSG00000020182
  
Biological name :Ddc
  
Synonyms : Aromatic-L-amino-acid decarboxylase / Ddc / O88533
  
Possible biological names infered from orthology : dopa decarboxylase / P20711
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 11814101
Gene end: 11898144
  
Corresponding Affymetrix probe sets: 10384378 (MoGene1.0st)   1426215_at (Mouse Genome 430 2.0 Array)   1430591_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068525
Ensembl peptide - ENSMUSP00000105286
Ensembl peptide - ENSMUSP00000121096
Ensembl peptide - ENSMUSP00000136467
NCBI entrez gene - 13195     See in Manteia.
MGI - MGI:94876
RefSeq - XM_006514489
RefSeq - NM_001190448
RefSeq - NM_016672
RefSeq - XM_006514486
RefSeq - XM_006514487
RefSeq - XM_006514488
RefSeq Peptide - NP_001177377
RefSeq Peptide - NP_057881
swissprot - Q5SUV9
swissprot - O88533
swissprot - Q5SUV8
Ensembl - ENSMUSG00000020182
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddcENSDARG00000016494Danio rerio
 DDCENSGALG00000013094Gallus gallus
 DDCENSG00000132437Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hdc / P23738 / histidine decarboxylase / P19113*ENSMUSG0000002736053
Gadl1 / glutamate decarboxylase like 1 / Q6ZQY3*ENSMUSG0000005688024
Gad1 / P48318 / glutamate decarboxylase 1 / Q99259*ENSMUSG0000007088024
Gad2 / P48320 / glutamic acid decarboxylase 2 / Q05329* / glutamate decarboxylase 2*ENSMUSG0000002678723
Csad / Q9DBE0 / Cysteine sulfinic acid decarboxylase / Q9Y600*ENSMUSG0000002304423


Protein motifs (from Interpro)
Interpro ID Name
 IPR002129  Pyridoxal phosphate-dependent decarboxylase
 IPR010977  Aromatic-L-amino-acid decarboxylase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR021115  Pyridoxal-phosphate binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009636 response to toxic substance IDA
 biological_processGO:0010259 multicellular organism aging IEA
 biological_processGO:0015842 aminergic neurotransmitter loading into synaptic vesicle IEA
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0033076 isoquinoline alkaloid metabolic process IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0042416 dopamine biosynthetic process IEA
 biological_processGO:0042423 catecholamine biosynthetic process IEA
 biological_processGO:0042427 serotonin biosynthetic process IEA
 biological_processGO:0046684 response to pyrethroid IEA
 biological_processGO:0052314 phytoalexin metabolic process IEA
 biological_processGO:0071312 cellular response to alkaloid IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004058 aromatic-L-amino-acid decarboxylase activity ISO
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0036468 L-dopa decarboxylase activity IEA


Pathways (from Reactome)
Pathway description
Catecholamine biosynthesis
Serotonin and melatonin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0002204 abnormal neurotransmitter physiology "aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddctm1.1Nwlh/Ddctm1.1Nwlh
Genetic Background: involves: C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ddctm1.1Nwlh/Ddctm1.1Nwlh
Genetic Background: involves: C57BL/6

 MP:0004217 salt-sensitive hypertension "sustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0005424 jerky movement "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
Genetic Background: B6.Cg-Dlg4tm1.1Tdoi

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0005582 increased renin activity "greater than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0005583 decreased renin activity "less than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

Allelic Composition: Ddctm1.1Nwlh/Ddctm1.1Nwlh
Genetic Background: involves: C57BL/6

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Ddctm1.1Nwlh/Ddctm1.1Nwlh
Genetic Background: involves: C57BL/6

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddctm1.1Nwlh/Ddctm1.1Nwlh
Genetic Background: involves: C57BL/6

 MP:0010070 decreased serotonin concentration "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ddctm1.1Nwlh/Ddctm1.1Nwlh
Genetic Background: involves: C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ddctm1.1Nwlh/Ddctm1.1Nwlh
Genetic Background: involves: C57BL/6

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
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Allelic Composition: Nfkbibtm1.2Rsch/Nfkbibtm1.2Rsch
Genetic Background: B6.129P2-Nfkbibtm1.2Rsch

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020182 Ddc / O88533 / Aromatic-L-amino-acid decarboxylase / P20711* / dopa decarboxylase*  / complex






 

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