Manteia - Molecule gene

ENSMUSG00000026787

Mus musculus

Features

Gene ID:	ENSMUSG00000026787

Biological name :	Gad2

Synonyms :	Gad2 / glutamic acid decarboxylase 2 / P48320

Possible biological names infered from orthology :	glutamate decarboxylase 2 / Q05329

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	A3
Gene start:	22622205
Gene end:	22693874

Corresponding Affymetrix probe sets:	10469672 (MoGene1.0st) 1421978_at (Mouse Genome 430 2.0 Array) 1429589_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000028123 NCBI entrez gene - 14417 See in Manteia. MGI - MGI:95634 RefSeq - NM_008078 RefSeq Peptide - NP_032104 swissprot - P48320 swissprot - Q548L4 Ensembl - ENSMUSG00000026787

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gad2	ENSDARG00000015537	Danio rerio
GAD2	ENSGALG00000040436	Gallus gallus
GAD2	ENSG00000136750	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gad1 / P48318 / glutamate decarboxylase 1 / Q99259*	ENSMUSG00000070880	65
Csad / Q9DBE0 / Cysteine sulfinic acid decarboxylase / Q9Y600*	ENSMUSG00000023044	45
Gadl1 / glutamate decarboxylase like 1 / Q6ZQY3*	ENSMUSG00000056880	41
Hdc / P23738 / histidine decarboxylase / P19113*	ENSMUSG00000027360	18
Ddc / O88533 / Aromatic-L-amino-acid decarboxylase / P20711* / dopa decarboxylase*	ENSMUSG00000020182	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR002129	Pyridoxal phosphate-dependent decarboxylase
IPR015421	Pyridoxal phosphate-dependent transferase, major domain
IPR015422	Pyridoxal phosphate-dependent transferase domain 1
IPR015424	Pyridoxal phosphate-dependent transferase
IPR021115	Pyridoxal-phosphate binding site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006540	glutamate decarboxylation to succinate	IEA
biological_process	GO:0019752	carboxylic acid metabolic process	IEA
biological_process	GO:0042136	neurotransmitter biosynthetic process	IEA
biological_process	GO:0042493	response to drug	IEA
cellular_component	GO:0000139	Golgi membrane	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0030424	axon	IDA
cellular_component	GO:0030672	synaptic vesicle membrane	IEA
cellular_component	GO:0031225	anchored component of membrane	IEA
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
cellular_component	GO:0042734	presynaptic membrane	IEA
cellular_component	GO:0045202	synapse	IDA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IEA
cellular_component	GO:0060077	inhibitory synapse	IEA
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0004351	glutamate decarboxylase activity	IEA
molecular_function	GO:0016595	glutamate binding	IEA
molecular_function	GO:0016829	lyase activity	IEA
molecular_function	GO:0016831	carboxy-lyase activity	IEA
molecular_function	GO:0030170	pyridoxal phosphate binding	IEA
molecular_function	GO:0046982	protein heterodimerization activity	IEA

Pathways (from Reactome)

Pathway description

GABA synthesis, release, reuptake and degradation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Gad1^tm1Tama/Gad1^tm1Tama,Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Gad1^tm1Oba/Gad1^tm1Oba,Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0000243	myoclonus	"involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Gad2^tm1Miya/Gad2^tm1Miya Genetic Background: NOD.129P2-Gad2^tm1Miya
MP:0001363	increased anxiety-related response	"when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]	Show Allelic Composition: Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Gad2^tm1Oba/Gad2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0001869	pancreas inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Gad2^tm1Miya/Gad2^tm1Miya Genetic Background: NOD.129P2-Gad2^tm1Miya
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Fus^{tm1.1(KOMP)Vlcg}/Fus^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fus^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Gad1^tm1Tama/Gad1^tm1Tama,Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0002062	abnormal conditioning behavior	"inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gad2^tm2(cre)Zjh/?,Rai1^tm2.1Luo/Rai1^tm2.1Luo Genetic Background: either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gad1^tm1Oba/Gad1^tm1Oba Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Gad2^tm1Bae/Gad2^tm1Bae Genetic Background: involves: 129X1/SvJ * NOD Allelic Composition: Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Gad2^tm1Miya/Gad2^tm1Miya Genetic Background: NOD.129P2-Gad2^tm1Miya Allelic Composition: Gad2^tm1Oba/Gad2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gad1^tm1Oba/Gad1^tm1Oba Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Gad2^tm1Bae/Gad2^tm1Bae Genetic Background: involves: 129X1/SvJ * NOD Allelic Composition: Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Gad2^tm1Miya/Gad2^tm1Miya Genetic Background: NOD.129P2-Gad2^tm1Miya Allelic Composition: Gad1^tm1Oba/Gad1⁺,Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dlx5^{tm1(cre/ERT2)Zjh}/Dlx5⁺ Genetic Background: C57BL/6-Dlx5^{tm1(cre/ERT2)Zjh} Allelic Composition: Gad2^tm2(cre)Zjh/Gad2^tm2(cre)Zjh Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL Allelic Composition: Gad2^tm1.1Ksvo/Gad2^tm1.1Ksvo Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J
MP:0002204	abnormal neurotransmitter physiology	"aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Gad2^tm1Oba/Gad2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Gad1^tm1Oba/Gad1^tm1Oba,Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0002206	abnormal CNS synaptic transmission	"defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Stip1^tm1.2Mamp/Stip1⁺ Genetic Background: involves: C57BL/6
MP:0002272	abnormal nervous system electrophysiology	"anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gad1^tm1Tama/Gad1^tm1Tama,Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0002574	increased vertical activity	"greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fus^{tm1.1(KOMP)Vlcg}/Fus^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fus^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002578	impaired ability to fire action potentials	"anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Stip1^tm1.2Mamp/Stip1⁺ Genetic Background: involves: C57BL/6
MP:0002887	resistance to pharmacologically induced seizures	"ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]	Show Allelic Composition: Stip1^tm1.2Mamp/Stip1⁺ Genetic Background: involves: C57BL/6
MP:0002945	abnormal inhibitory postsynaptic currents	"defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Stip1^tm1.2Mamp/Stip1⁺ Genetic Background: involves: C57BL/6
MP:0003019	increased circulating chloride level	"elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Fus^{tm1.1(KOMP)Vlcg}/Fus^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fus^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003052	omphalocele	"protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Gad1^tm1Tama/Gad1^tm1Tama,Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0003063	increased coping response	"enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0003477	abnormal nerve fiber response	"anomaly in the electrophysiological recordings from a single or several nerve fiber(s)" [Nmice:Neuromice Consortium Submission]	Show Allelic Composition: Gad1^tm1Tama/Gad1^tm1Tama,Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0003862	decreased aggression towards males	"when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Gad2^tm1Oba/Gad2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0003997	tonic-clonic seizures	"increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fus^{tm1.1(KOMP)Vlcg}/Fus^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fus^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005332	abnormal amino acid level	"aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gad2^tm1Bae/Gad2^tm1Bae Genetic Background: involves: 129X1/SvJ * NOD
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Gad2^tm1Miya/Gad2^tm1Miya Genetic Background: NOD.129P2-Gad2^tm1Miya
MP:0005633	increased circulating sodium level	"greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Fus^{tm1.1(KOMP)Vlcg}/Fus^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fus^{tm1.1(KOMP)Vlcg}/Ucd
MP:0009142	decreased prepulse inhibition	"decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fus^{tm1.1(KOMP)Vlcg}/Fus^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fus^{tm1.1(KOMP)Vlcg}/Ucd
MP:0009454	impaired contextual conditioning	"decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gad2^tm2(cre)Zjh/?,Rai1^tm2.1Luo/Rai1^tm2.1Luo Genetic Background: either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)
MP:0009456	impaired cued conditioning behavior	"decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gad2^tm2(cre)Zjh/?,Rai1^tm2.1Luo/Rai1^tm2.1Luo Genetic Background: either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)
MP:0010819	primary atelectasis	"nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Gad1^tm1Tama/Gad1^tm1Tama,Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Gad1^tm1Oba/Gad1^tm1Oba,Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Gad1^tm1Oba/Gad1⁺,Gad2^tm1Oba/Gad2^tm1Oba Genetic Background: involves: C57BL/6 * CBA
MP:0011269	increased excitatory postsynaptic current amplitude	"increase in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]	Show Allelic Composition: Gabrd^tm1.1Jmag/Gabrd⁺,Gad2^tm2(cre)Zjh/Gad2⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0011987	abnormal GABAergic neuron physiology	"any functional anomaly of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter" [PMID:8787741]	Show Allelic Composition: Gabrd^tm1.1Jmag/Gabrd⁺,Gad2^tm2(cre)Zjh/Gad2⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000026787	Gad2 / P48320 / glutamic acid decarboxylase 2 / Q05329* / glutamate decarboxylase 2*	/ complex
ENSMUSG00000070880	Gad1 / P48318 / glutamate decarboxylase 1 / Q99259*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr